Reflexogenic contraction of the ileo-cecal sphincter in the cat following small or large intestinal distension.

Acta Physiologica Scandinavica
P E Pahlin, J Kewenter

Abstract

The effect of distension of a small or large intestinal loop on the ileo-cecal sphincter (ICS) in the cat was studied with a flow-recording technique. Distension of a small or large intestinal loop, isolated from the adjacent intestine, but with its mesenteric vascular and nervous supply intact, elicited a contraction of the ICS concomitant with an inhibition of the adjacent large and small intestinal motility. Vagal and pelvic nerve section did not affect the response to distension of the ICS nor exclusion of the adrenal glands from the circulation. The sphincter reflex could be entirely or almost entirely eliminated by cutting both the splanchnic and lumbar colonic nerves, but not one or the other. Spinal anesthesia bocked the reflex response indicating a spinal reflex arc. The reflex persisted after atropine and propranolol, while both guanethidine and phenoxybenzamine completely abolished the reflex contraction of the sphincter. The present results indicate that the excitatory intestino-ileo-cecal sphincteric reflex is a spinal reflex with the main afferent and/or efferent fibres located within the major splanchnic and lumbar colonic nerves. The excitatory motor response in the sphincter is adrenergic and mediated via alpha...Continue Reading

References

Apr 1, 1976·Acta Physiologica Scandinavica·P E Pahlin, J Kewenter
May 1, 1985·Acta Physiologica Scandinavica·H HedlundS Nordgren
Jan 1, 1974·Acta Physiologica Scandinavica·H Abrahamsson
Jan 1, 1968·Acta Physiologica Scandinavica·B JohanssonB Ljung
Sep 11, 1966·The American Journal of Physiology·M L KelleyJ A Deweese
Apr 1, 1965·Acta Physiologica Scandinavica·B JOHANSSONB LJUNG
Jan 1, 1959·Acta Physiologica Scandinavica. Supplementum·N G KOCK

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Citations

Apr 1, 1976·Acta Physiologica Scandinavica·P E Pahlin, J Kewenter
Oct 1, 1979·Acta Physiologica Scandinavica·R EdinJ Kewenter
Mar 1, 1988·Gut·S F PhillipsP S Kamath
Nov 1, 1976·Acta Physiologica Scandinavica·H AhlmanJ Kewenter
May 1, 1990·Pain·T J Ness, G F Gebhart
Jul 6, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T KajimotoI J Cook
Jan 1, 1980·Journal of Neural Transmission·R EdinJ Kewenter

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