Reflux esophagitis and the risk of stroke in young adults: a 1-year population-based follow-up study

Stroke; a Journal of Cerebral Circulation
Jau-Jiuan SheuHerng-Ching Lin

Abstract

Reflux esophagitis (RE) is the most common manifestation of gastro-esophageal reflux disease with esophageal injury. To the best of our knowledge, there has been no specific study to evaluate the risk of stroke after diagnosis of RE in young adults. This study aims to evaluate the risk of stroke among RE patients aged 18 to 50 years during a 1-year period after diagnosis of RE compared to a cohort of non-RE patients during the same period. This study used the Taiwan Longitudinal Health Insurance Database 2005. A total of 2340 RE patients were included as the study cohort and 11 700 non-RE patients were included as the comparison cohort. Each patient was individually tracked for 1 year from the index ambulatory visit to identify those in whom stroke developed. Out of the sample of 14 040 patients, 78 patients (0.56%) had strokes develop during the 1-year follow-up period: 22 from the study cohort (0.94% of the RE patients) and 56 from the comparison cohort (0.48% of patients without RE). Patients with RE were 1.68-times more likely to have strokes develop (95% confidence interval, 1.03-2.76) than patients in the comparison cohort during the follow-up period after adjusting for patients' medical comorbidities, such as hypertensio...Continue Reading

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Citations

Jan 25, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J-H KangH-C Lin
Aug 1, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Shih-Han HungShiu-Dong Chung
Oct 22, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Cheng-Yang HsiehMing-Liang Lai
Dec 6, 2012·Journal of the American Medical Directors Association·Philipe de Souto BarretoYves Rolland
Feb 5, 2013·The Laryngoscope·Jiunn-Horng KangHerng-Ching Lin
Jun 8, 2012·Neurourology and Urodynamics·Jiunn-Horng KangHerng-Ching Lin
Jan 30, 2014·Medical Hypotheses·Wei-Shih Tseng
Aug 11, 2016·International Forum of Allergy & Rhinology·Peter A RosenthalMulugeta Gebregziabher
Oct 4, 2012·Epilepsia·Cheng-Yang HsiehSwu-Jane Lin
Jan 7, 2020·Journal of Biomedical Informatics·Haodi ZhongRobert Gwadera
Feb 21, 2021·Asthma Research and Practice·A CorlateanuN Siafakas

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