PMID: 6026666Jul 7, 1967Paper

Reformation of functional liver polyribosomes from ribosome monomers in the absence of RNA synthesis

Science
G A Stewart, E Farber

Abstract

The administration to rats of the ethyl analog of methionine, ethionine, results in the rapid decrease in the hepatic concentration of adenosine triphosphate followed by an extensive disaggregation of polysomes to ribosome monomers and a concomitant inhibition of protein synthesis. These effects are readily reversed by the injection of methionine or precursors of adenine nucleotides such as adenine. The reformation of liver polyribosomes in such animals following the administration of adenine plus methionine was found to occur under conditions in which new RNA synthesis was markedly inhibited. Free messenger RNA without attached ribosomes must be capable of remaining functionally active in the liver cytoplasm for many hours.

References

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Citations

May 22, 1971·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·B C WuM F Argus
Jan 1, 1973·Advances in Enzyme Regulation·T K Shires, H C Pitot
Jan 28, 1971·Biochimica Et Biophysica Acta·W Hoerz, K S McCarty
Sep 17, 1969·Biochimica Et Biophysica Acta·A OlerK H Shull
Oct 1, 1968·Experimental Cell Research·H W ChenP A Kitos
Aug 15, 1969·Biochemical and Biophysical Research Communications·D S SarmaH Sidransky
Nov 1, 1970·The American Journal of Medicine·J D JdahE K McLean
Sep 1, 1977·Toxicology and Applied Pharmacology·D E Berry, M A Friedman
Feb 23, 1973·Biochimica Et Biophysica Acta·L F PanchenkoN G Schuppe

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