Refractory hypothalamic adenylate cyclase in anorectic tumor-bearing rats: implications for NPY-induced feeding

Brain Research
W T ChanceJ E Fischer

Abstract

Although isoproterenol stimulated adenylate cyclase activity in hypothalamic membranes taken from freely-feeding, food-restricted or nonanorectic tumor-bearing rats, the response was greatly reduced in anorectic tumor-bearing rats. The addition of NPY to the membrane preparation inhibited adenylate cyclase activity in hypothalamus taken from freely-feeding and food-restricted rats, but NPY-inhibitory activity was significantly reduced in both groups of tumor-bearing rats. These results suggest that cyclic AMP formation is refractory in anorectic tumor-bearing rats, and that NPY-induced inhibition of hypothalamic adenylate cyclase is reduced in tumor-bearing rats prior to the onset of significant anorexia. Therefore, NPY-induced feeding may be reduced in tumor-bearing organisms due to a dysfunction in the cyclic AMP second messenger system.

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Citations

Dec 19, 2013·American Journal of Physiology. Endocrinology and Metabolism·Kiyoshi TerawakiYasuhito Uezono
Jul 3, 2004·Nutrition and Cancer·William T ChanceJ Howard James
Apr 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mellar P DavisSusan B LeGrand
Feb 24, 2016·Oncogenesis·P E Porporato
Nov 5, 1998·Regulatory Peptides·W T ChanceA Balasubramaniam

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