Refractory neuromyelitis optica spectrum disorder in systemic lupus erythematosus successfully treated with rituximab

Lupus
K ShidaharaJ Wada

Abstract

We present a case of a woman with systemic lupus erythematosus (SLE) who had refractory episodes of neuromyelitis optica spectrum disorder (NMOSD) and was successfully treated with rituximab. She was positive for anti-aquaporin-4 (AQP4) antibody and had typical cranial and longitudinally extended spinal lesions but no optic nerve involvement. There is no established treatment for NMOSD/SLE overlap cases. Our experience suggests that rituximab may be effective for patients with combined SLE and anti-AQP4 antibody-positive NMOSD.

References

Aug 10, 2005·The Journal of Experimental Medicine·Vanda A LennonShannon R Hinson
May 24, 2006·Neurology·D M WingerchukB G Weinshenker
Aug 21, 2007·Lancet Neurology·Dean M WingerchukBrian G Weinshenker
Jan 16, 2008·Archives of Neurology·Sean J PittockBrian G Weinshenker
Apr 28, 2011·Arthritis Care & Research·Jason R KolfenbachSterling G West
May 16, 2015·Neurology. Neuroimmunology and Neuroinflammation·Jeffrey L BennettChristine Stadelmann
May 2, 2017·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Masoud EtemadifarEmad Fayyazi

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Citations

Apr 10, 2021·Journal of the Neurological Sciences·John G Hanly, Murat Inanç

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