Refractory overactive bladder: a common problem?

International Urogynecology Journal
Ulrich SchwantesAndreas Wiedemann

Abstract

Unsatisfactory treatment outcome sometimes is described as frequently occurring in patients treated with first-line therapy for overactive bladder (OAB). The present article reviews the different circumstances which may result in failure to respond to lifestyle interventions, behavioral therapy, and/or antimuscarinic treatment. An extensive literature search was conducted to identify relevant articles on pathophysiological, clinical, and pharmacological aspects of refractory OAB. Missing definition, unrealistic individual expectation of treatment outcomes, lack of communication between physician and patient as well as pathophysiological and pharmacological processes were identified as relevant for failure to respond to first-line OAB treatment. Increase of patient's motivation to adhere to the prescribed treatment, critical examination of the patient in regard to the initial diagnosis, and individual adjustment of antimuscarinic therapy may be appropriate tools to improve treatment outcome in OAB patients. Overall, the incidence of refractory OAB seems to be overestimated. There are several approaches to improve therapy results.

References

Jan 1, 1988·European Journal of Clinical Pharmacology·J DouchampsA Herchuelz
Jan 1, 1996·European Journal of Clinical Pharmacology·E LukkariP J Neuvonen
Mar 27, 1998·European Journal of Clinical Pharmacology·E LukkariP J Neuvonen
Jan 5, 2002·World Journal of Urology·J WeferU Jonas
Aug 14, 2003·Experimental Gerontology·Klaus Turnheim
May 24, 2005·International Journal of Clinical Pharmacology and Therapeutics·W J J KrauwinkelM E J Taekema-Roelvink
Jun 22, 2005·Clinical Pharmacokinetics·Oxana DoroshyenkoUwe Fuhr
Aug 2, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Tim SchneiderMartin C Michel
Apr 6, 2006·Clinical Pharmacokinetics·Andrej Skerjanec
Jul 19, 2006·Neurourology and Urodynamics·M HorstmannK D Sievert
Mar 13, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·C Wong, P Duggan
Apr 17, 2009·The Cochrane Database of Systematic Reviews·G Peter Herbison, Edwin P Arnold
Apr 25, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Joachim GeyerErnst Petzinger
Aug 22, 2009·The Journal of Urology·Stéphane BolducMicheline Hamel
Sep 19, 2009·International Journal of Clinical Pharmacology and Therapeutics·B K MalhotraR Sachse
Nov 17, 2009·BJU International·Joshua S BennerLinda Brubaker
Nov 4, 2010·Archives of Gynecology and Obstetrics·Katharina JundtUrsula Peschers
Jun 7, 2011·International Urology and Nephrology·Prashanth KanagarajahAngelo E Gousse
Nov 29, 2011·World Journal of Urology·Jasmin KranzJoachim Geyer
Dec 14, 2011·The Cochrane Database of Systematic Reviews·James B DuthieDon Wilson
Apr 19, 2012·BMJ : British Medical Journal·Serge P MarinkovicChristina M Marinkovic
Jan 1, 2012·International Journal of Immunopathology and Pharmacology·R NardulliM Megna
Oct 25, 2012·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Marcus J Drake
Oct 27, 2012·The Journal of Urology·E Ann GormleyUNKNOWN Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction
Feb 12, 2013·Maturitas·Dudley RobinsonLinda Cardozo
Jul 4, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G Alessandro DigesuVik Khullar
Oct 30, 2013·Current Medical Research and Opinion·Howard B GoldmanFady Ntanios
Jun 6, 2014·International Journal of Clinical Practice·S A KaplanUNKNOWN Assessment of Fesoterodine after Tolterodine ER (AFTER) Study Group
Jul 13, 2014·Current Urology Reports·Bassem S Wadie
Jul 16, 2014·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Geneviève NadeauStéphane Bolduc

❮ Previous
Next ❯

Citations

Nov 8, 2016·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Kirschner-Hermanns RuthHuppertz Nadine
Sep 29, 2017·Female Pelvic Medicine & Reconstructive Surgery·Alexis M TranSylvia M Botros
Jul 31, 2019·Neurourology and Urodynamics·Eric S RovnerStefan De Wachter
Nov 23, 2020·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·X Gamé, V Phé

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
augmentation

Software Mentioned

BIOSIS
EMBASE
MEDLINE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.