REGγ is associated with multiple oncogenic pathways in human cancers.

BMC Cancer
Jing HeXiaotao Li

Abstract

Recent studies suggest a role of the proteasome activator, REGγ, in cancer progression. Since there are limited numbers of known REGγ targets, it is not known which cancers and pathways are associated with REGγ. REGγ protein expressions in four different cancers were investigated by immunohistochemistry (IHC) analysis. Following NCBI Gene Expression Omnibus (GEO) database search, microarray platform validation, differential expressions of REGγ in corresponding cancers were statistically analyzed. Genes highly correlated with REGγ were defined based on Pearson's correlation coefficient. Functional links were estimated by Ingenuity Core analysis. Finally, validation was performed by RT-PCR analysis in established cancer cell lines and IHC in human colon cancer tissues Here, we demonstrate overexpression of REGγ in four different cancer types by micro-tissue array analysis. Using meta-analysis of publicly available microarray databases and biological studies, we verified elevated REGγ gene expression in the four types of cancers and identified genes significantly correlated with REGγ expression, including genes in p53, Myc pathways, and multiple other cancer-related pathways. The predicted correlations were largely consistent with...Continue Reading

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Citations

May 6, 2015·International Journal of Oncology·Xiaoping XuQianming Chen
Nov 22, 2014·Cell Death and Differentiation·S LiP Wang
Jul 24, 2015·Apoptosis : an International Journal on Programmed Cell Death·Anja MoncsekRalf Stohwasser
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Methods Mentioned

BETA
ubiquitination
Genotyping
electrophoresis
PCR
transfecting

Software Mentioned

IPA ( Pathway Analysis )
MAS5
Ingenuity system
Ingenuity
GEOquery
Ingenuity Knowledge Base
GEO
Limma
R

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