Regarding the algorithm for the diagnosis of early mycosis fungoides proposed by the International Society for Cutaneous Lymphomas: suggestions from routine histopathology practice

Journal of Cutaneous Pathology
Gerardo FerraraLorenzo Cerroni

Abstract

Routine clinicopathologic practice is expected to refine/validate the scoring system proposed in 2005 by the International Society for Cutaneous Lymphomas (ISCL) for the diagnosing early mycosis fungoides (eMF), classical type. An evaluation of 72 cases of erythematous and scaling dermatoses was employed with a partial implementation of the ISCL algorithm. The selected cases fulfilled the clinical criteria proposed by the ISCL; routine histopathology allowed to reach the ISCL minimum score for a diagnosis of eMF in 45 cases. A clonal T-cell population was found in 4 out of 12 cases tested with the polymerase chain reaction, three of which with an already established clinicopathologic diagnosis of eMF. An aberrant immunophenotype was found in 11 cases, all of which already labeled as eMF on the basis of clinical and histopathologic features. 6 out of 27 patients with inconclusive clinicopathologic data underwent a new skin biopsy, which allowed to reach a diagnosis of eMF in two cases. The diagnosis of eMF still rests upon clinical features and conventional histology; a new skin biopsy is recommended for cases with no clear-cut diagnostic features.

References

Jan 1, 1979·The American Journal of Dermatopathology·J L Sanchez, A B Ackerman
Dec 1, 1992·The American Journal of Dermatopathology·D King-Ismael, A B Ackerman
Dec 1, 1988·The American Journal of Dermatopathology·B J Nickoloff
Dec 1, 1995·The American Journal of Surgical Pathology·B R SmollerM Hendrickson
Jun 21, 2005·Journal of the American Academy of Dermatology·E Mary WainRobin Russell-Jones
Nov 29, 2005·Journal of the American Academy of Dermatology·Nicola PimpinelliUNKNOWN International Society for Cutaneous Lymphoma

❮ Previous
Next ❯

Citations

Jun 28, 2001·Journal of Cutaneous Pathology·E J Glusac
Feb 11, 2010·The American Journal of Dermatopathology·Gerardo FerraraCatherine M Stefanato
Oct 1, 2014·Archives of Pathology & Laboratory Medicine·David P ArpsAlexandra C Hristov
Jun 1, 2014·Surgical Pathology Clinics·Laura B Pincus
Mar 2, 2012·The Journal of Investigative Dermatology·Yaohua ZhangYouwen Zhou
Oct 23, 2009·Dermatologic Therapy·John A Zic
Dec 12, 2012·Contact Dermatitis·Luis M Valladares NarganesManuel Angel Rodriguez Prieto
Apr 9, 2015·British Journal of Haematology·John T Sandlund, Sherrie L Perkins
Dec 1, 2012·Anais Brasileiros De Dermatologia·Thamy YamashitaSilvio Alencar Marques
Mar 26, 2013·American Journal of Clinical Pathology·Sophie X SongJonathan W Said
Feb 5, 2010·Journal of Cutaneous Medicine and Surgery·Elena PopeArline Tsuchiya
Jun 28, 2017·The American Journal of Dermatopathology·Amanda PereiraLorenzo Cerroni
Apr 17, 2019·Journal of Cutaneous Pathology·Huma ShamimNneka Comfere
Sep 13, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristina TheodulozGuillermo Schmeda-Hirschmann
Apr 10, 2014·American Journal of Clinical Pathology·Robin T Vollmer
Nov 22, 2014·The American Journal of Dermatopathology·Christine S AhnOmar P Sangüeza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.