Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors

Nutrients
Ewa Baranowska-WójcikAnna Winiarska-Mieczan

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized, among others, by abnormally low levels of the neurotransmitter acetylcholine in the brain. Acetylcholinesterase (AChE) plays a significant role in the process through hydrolysis of the acetylcholine neurotransmitter. Currently, the main method for treatment of AD at a symptomatic stage entails administration of AChE inhibitors to patients diagnosed with the disease. However, it is also possible to take certain steps to treat AD by delivering inhibitors with food. There is a growing body of evidence to suggest that tea (Camellia sinensis) shows numerous beneficial properties, including improving cognitive abilities. This is particularly important in the case of AD patients. The study assessed the impact of brewing conditions on the inhibition of AChE activity observed in tea extracts (black, white, or fruit). Our study revealed that neither temperature nor time of brewing influenced the respective infusions' ability to inhibit the activity of AChE. Anticholinesterase activity was observed in most of the different types of tea that were analyzed, with the highest rate of inhibition (30.46%-48.54%) evidenced in the Biofix Tea Wild Strawberry brand. ...Continue Reading

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Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gertrud E MorlockMichel Dubourdeaux
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Methods Mentioned

BETA
protein folding
transgenic

Software Mentioned

Statistica

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