Regenerate augmentation with bone marrow concentrate after traumatic bone loss.

Orthopedic Reviews
Jan GessmannDominik Seybold

Abstract

Distraction osteogenesis after post-traumatic segmental bone loss of the tibia is a complex and time-consuming procedure that is often complicated due to prolonged consolidation or complete insufficiency of the regenerate. The aim of this feasibility study was to investigate the potential of bone marrow aspiration concentrate (BMAC) for percutaneous regenerate augmentation to accelerate bony consolidation of the regenerate. Eight patients (age 22-64) with an average posttraumatic bone defect of 82.4 mm and concomitant risk factors (nicotine abuse, soft-tissue defects, obesity and/or circulatory disorders) were treated with a modified Ilizarov external frame using an intramedullary cable transportation system. At the end of the distraction phase, each patient was treated with a percutaneously injection of autologous BMAC into the centre of the regenerate. The concentration factor was analysed using flow cytometry. The mean follow up after frame removal was 10 (4-15) months. With a mean healing index (HI) of 36.9 d/cm, bony consolidation of the regenerate was achieved in all eight cases. The mean concentration factor of the bone marrow aspirate was 4.6 (SD 1.23). No further operations concerning the regenerate were needed and no ...Continue Reading

Citations

Apr 23, 2014·Regenerative Medicine·Mark E FlemingIan Valerio
Jul 24, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·L SununliganonL K Cheung
Aug 8, 2014·Journal of Periodontology·Maria J H NagataEdilson Ervolino
Mar 30, 2016·Progress in Polymer Science·Fa-Ming Chen, Xiaohua Liu
Jan 21, 2018·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·R VerboketI Marzi
Mar 17, 2015·International Orthopaedics·Ivo Dumic-CuleSlobodan Vukicevic
Oct 9, 2019·The Journal of Craniofacial Surgery·Yasser Nabil El HadidiMarwa El Kassaby
Aug 5, 2016·JBJS Reviews·Jocelyn ComptonS Robert Rozbruch
Apr 10, 2019·Journal of Translational Medicine·Richard SchäferJason L Dragoo
Apr 16, 2019·World Journal of Gastroenterology : WJG·Mohammed Mohammed El-Said, Sameh Hany Emile
Jul 19, 2017·Der Orthopäde·Valentin RauschJan Geßmann
Nov 22, 2019·Current Reviews in Musculoskeletal Medicine·Matthew T KingeryEric J Strauss
Jun 10, 2021·The Journal of the American Academy of Orthopaedic Surgeons·Severin RuossSamuel R Ward
Jul 3, 2021·International Journal of Molecular Sciences·Jishizhan ChenWenhui Song

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Methods Mentioned

BETA
X-ray
bone
density gradient centrifugation
flow cytometry
bone marrow aspiration

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