PMID: 11329128May 1, 2001Paper

Regenerating optic fibers correct large-scale errors by random growth: evidence from in vivo imaging

The Journal of Comparative Neurology
A J Dawson, R L Meyer

Abstract

Regenerating optic fibers in goldfish make large-scale errors when they invade tectum and subsequently correct these to generate a projection with moderate retinotopic order by 1 month. The behavior of fibers underlying these extensive rearrangements is not well understood. To clarify this, we have imaged optic fibers in living adult goldfish at 2-4 weeks of regeneration. A small number of neighboring retinal ganglion cells were labeled with microinjections of DiI and imaged in the dorsal tectum with a cooled CCD camera on a fluorescence microscope for 5 to 8 hours. Nearly all fibers were simple unbranched processes and had endings that were highly dynamic showing both growth and retraction. Fibers from dorsal retina that normally innervate ventral tectum were frequently observed in dorsal tectum. These ectopic fibers oscillated more frequently between growth and retraction and retracted more often than ventral optic fibers. Like retinotopic fibers, ectopic fibers exhibited net growth but they showed no apparent directional preference toward their retinotopic position. In contrast, large errors along the anterior-posterior axis corresponding to nasal-temporal retina were rare and there was no differential behavior that distingu...Continue Reading

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Citations

Sep 5, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cynthia M Solek, Marc Ekker
Mar 5, 2016·Experimental Neurology·Jeffrey P Rasmussen, Alvaro Sagasti
Nov 6, 2012·The Journal of Comparative Neurology·Hugh D SimpsonGeoffrey J Goodhill
Jul 5, 2003·Science·Edward S RuthazerHollis T Cline

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