PMID: 8951458Dec 1, 1996Paper

Regeneration after tall hair cell damage following severe acoustic trauma in adult pigeons: correlation between cochlear morphology, compound action potential responses and single fiber properties in single animals

Hearing Research
M MüllerR Klinke

Abstract

The time course of recovery of compound action potential (CAP) thresholds was observed in individual adult pigeons after severe acoustic trauma. Pigeons were overstimulated with a tone of 0.7 kHz and 136-142 dB SPL presented to one ear for 1 h under general anesthesia. Recovery of CAP audiograms was monitored at regular intervals after trauma. A new semi-stereotaxic approach to the peripheral part of the auditory nerve was developed. This permitted activity from single auditory nerve fibers to be recorded over a wide range of characteristic frequencies (CFs), including high CFs, without having to open the inner ear. Single unit recordings were made after three weeks and after 4 or more months of recovery. The time course of recovery, the single unit properties, and the morphological status of the basilar papilla were correlated. The CAP was abolished in all animals after overstimulation. Three groups of animals were identified according to the functional recovery of the CAP thresholds recorded at regular intervals with implanted electrodes: Group 1: Fast functional recovery starting immediately after trauma, followed by recovery to pre-exposure values within 3 weeks. Group 2: Slow functional recovery of threshold starting 1-2 w...Continue Reading

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Citations

Jun 14, 2002·Hearing Research·Dianne DurhamDouglas A Girod
Oct 4, 2002·Hearing Research·Rainer HartmannRainer Klinke
Dec 22, 1999·Hearing Research·C KöpplG A Manley
Feb 21, 2003·Current Opinion in Neurobiology·Olivia Bermingham-McDonogh, Edwin W Rubel
Oct 20, 2006·The Journal of Experimental Biology·Michael E SmithArthur N Popper

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