PMID: 490187Jun 1, 1979Paper

Regeneration and myelination in autonomic ganglia transplanted to intact brain surfaces

Journal of Neurocytology
J M Rosenstein, M W Brightman

Abstract

Fragments of superior cervical ganglia (SCG) from donor rats between newborn and three months of age were transplanted either into the fourth ventricle, onto the dorsal surface of the medulla or in contact with the area postrema of recipient rats aged 6--14 days (allografts) and 3--4 weeks (autografts). Except for the meninges, the entire brain surface and parenchyma was undisturbed. The regenerative capacity of the transplanted ganglia and its interaction with the brain surfaces was followed for post-operative periods between 1 h and six months. Both ependymal and glial cells reacted to the transplant even though there was no mechanical damage to the brain. Ependymal cells developed luminal fronds that projected into the ventricle and the subpial glia displayed a very subtle gliosis in the form of thin multi-laminated processes. Schwann cells from the transplant tended to cover the free surfaces of the brain. The transplants, often incorporated into the stroma of the choroid plexus, received an extensive vascular supply of both fenestrated and non-fenestrated vessels. In contrast to SCG in tissue culture, the perinatal explants quickly degenerated while all those from older donors, at least 3--4 weeks of age, regenerated brisk...Continue Reading

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Citations

Jun 1, 1981·Journal of Neurocytology·J M Rosenstein, M W Brightman
Jan 1, 1992·The European Journal of Neuroscience·Ferdinando RossiPiergiorgio Strata
Aug 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A TubaZ Fülöp
Jan 1, 1987·Annals of the New York Academy of Sciences·J M Rosenstein
Apr 10, 1989·Brain Research·S L SkirbollL Olson
Jan 1, 1984·Central Nervous System Trauma : Journal of the American Paralysis Association·J J BernsteinD W Hoovler
May 15, 1988·The Journal of Comparative Neurology·J M Krum, J M Rosenstein
Apr 15, 1987·The Journal of Comparative Neurology·J M Krum, J M Rosenstein
Aug 26, 1983·Science·J M Rosenstein, M W Brightman

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