DOI: 10.1101/509331Jan 2, 2019Paper

Regeneration in the absence of a blastema requires cell division but is not tied to wound healing in the ctenophore Mnemiopsis leidyi

BioRxiv : the Preprint Server for Biology
Julia Ramon MateuMark Q Martindale

Abstract

Background: The ability to regenerate is a widely distributed but highly variable trait among metazoans. A variety of modes of regeneration has been described for different organisms, however, many questions regarding the origin and evolution of these strategies remain unanswered. Most species of ctenophore (or "comb jellies"), a clade of marine animals that branch off at the base of the animal tree of life, possess an outstanding capacity to regenerate. However, the cellular and molecular mechanisms underlying this ability are unknown. We have used the ctenophore Mnemiopsis leidyi as a system to study wound healing and adult regeneration and provide some first-time insights of the cellular mechanisms involved in the regeneration of one of the most ancient extant group of multicellular animals. Results: We show that cell proliferation is activated at the wound site and is indispensable for whole-body regeneration. Wound healing occurs normally in the absence of cell proliferation forming a scar-less wound epithelium. No blastema-like structure is generated at the cut site, rather undifferentiated cells assume the correct location of missing structures and differentiate in place. Pulse-chase experiments and surgical intervention...Continue Reading

Related Concepts

Cell Division
Epithelium
Biological Evolution
Nerve Regeneration
Natural Regeneration
Stereotypic Movement Disorder
Trees (plant)
Wound Healing
Injury Wounds
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