Regeneration of aged vocal fold: first human case treated with fibroblast growth factor

The Laryngoscope
Shigeru HiranoJuichi Ito

Abstract

Aged vocal folds are characterized by atrophy of the mucosa, which caused dysphonia and is difficult to treat. We have revealed a therapeutic potential of basic fibroblast growth factor (bFGF) for tissue regeneration of the aged vocal fold. We report here the first human case that has been treated with bFGF. Institutional review board-approved clinical human trial. A 63-year-old male with atrophied vocal folds was treated by local injection of 10 mug of bFGF into the left vocal fold under topical anesthesia. The effects of the injection were examined after 1 to 3 months by videostroboscopy, acoustic, and aerodynamic measurements. The atrophy of the vocal fold was improved at 1 week after the injection, and glottic gap disappeared. Aerodynamic and acoustic parameters also showed remarkable improvement. These positive effects were maintained up to 3 months. The first case with aged vocal folds treated with bFGF administration was presented. The results are encouraging, suggesting therapeutic effects of bFGF for atrophied vocal folds in human.

References

Jan 2, 2009·The Laryngoscope·Mihai MihaescuJ Paul Willging

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Citations

Sep 8, 2015·The Laryngoscope·Anete BrancoSusan L Thibeault
May 22, 2009·The Laryngoscope·Jonas Johnson
Jan 2, 2009·The Laryngoscope·Mihai MihaescuJ Paul Willging
May 15, 2012·Pharmacotherapy·Jennifer C SampA Simon Pickard
Nov 13, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery

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