Regeneration of Articular Cartilage in Lizard Knee from Resident Stem/Progenitor Cells

International Journal of Molecular Sciences
Lorenzo Alibardi

Abstract

The epiphysis of femur and tibia in the lizard Podarcis muralis can extensively regenerate after injury. The process involves the articular cartilage and metaphyseal (growth) plate after damage. The secondary ossification center present between the articular cartilage and the growth plate is replaced by cartilaginous epiphyses after about one month of regeneration at high temperature. The present study analyzes the origin of the chondrogenic cells from putative stem cells located in the growing centers of the epiphyses. The study is carried out using immunocytochemistry for the detection of 5BrdU-labeled long retaining cells and for the localization of telomerase, an enzyme that indicates stemness. The observations show that putative stem cells retaining 5BrdU and positive for telomerase are present in the superficial articular cartilage and metaphyseal growth plate located in the epiphyses. This observation suggests that these areas represent stem cell niches lasting for most of the lifetime of lizards. In healthy long bones of adult lizards, the addition of new chondrocytes from the stem cells population in the articular cartilage and the metaphyseal growth plate likely allows for slow, continuous longitudinal growth. When th...Continue Reading

References

May 1, 1970·American Zoologist·S B Simpson
Jan 27, 2000·Cell·E Fuchs, J A Segre
Aug 19, 2011·BMC Developmental Biology·Katherine E McLean, Matthew K Vickaryous
Aug 31, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Rebecca E FisherJeanne Wilson-Rawls
Jan 18, 2015·Developmental Biology·Thomas P Lozito, Rocky S Tuan

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Citations

Aug 18, 2017·The Journal of Experimental Biology·Kathy JacyniakMatthew K Vickaryous
Jan 21, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Lorenzo Alibardi
Mar 31, 2019·Journal of Translational Medicine·Ke XueKai Liu
Sep 19, 2019·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Lorenzo Alibardi

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