Regeneration of axons into the trochlear rootlet after anterior medullary lesions in the rat is specific for ipsilateral IVth nerve motoneurones

The Journal of Comparative Neurology
A DerouicheJ Sievers

Abstract

The fibre projection from the IVth nerve nucleus to the superior oblique muscle was determined quantitatively in the normal rat by defining fibre numbers in transverse sections of the IVth nerve, and neurone numbers after retrograde labelling by horseradish peroxidase (HRP) injection into the muscle. There were 183 +/- 27 (S.E.) labelled neurones in the nucleus contralateral to the injected muscle and only 2 +/- 1 ipsilateral. The ipsilateral fibre number was 234 +/- 7 and the cell/axon ratio 0.8 +/- 0.1. Extensive analysis of all HRP retrogradely labelled material revealed no central fibre contribution to the IVth nerve other than from neurones resident in the trochlear nucleus. The central portion of the trochlear nerve tract was severed at its point of decussation in the anterior medullary velum. Ninety days after lesion, 10 +/- 4 (6% of control) neurones were labelled in the ipsilateral trochlear nucleus; none were labelled in the contralateral nucleus or in any other part of the midbrain, pons, medulla, or cerebellum. The number of myelinated fibres in the IVth nerve had decreased to 21 +/- 5 (9% of control) so that the cell/axon ratio was 0.4 +/- 0.2, thus suggesting that a single motoneurone has more fibres after lesion....Continue Reading

References

Feb 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M M Mesulam
Jan 1, 1992·Trends in Neurosciences·R E Coggeshall
Jun 1, 1992·Trends in Neurosciences·P G Clarke
Jul 1, 1992·Journal of Neurobiology·M C BrownV H Perry
Jan 1, 1991·Journal of Cell Science. Supplement·M SendtnerH Thoenen
Nov 15, 1987·The Journal of Comparative Neurology·M B Heaton
Dec 1, 1986·The Journal of Comparative Neurology·E H MurphyR B Baker
Jun 1, 1974·The Anatomical Record·M M SalpeterH H Feng
Mar 1, 1970·Experimental Neurology·E ManniP L Deriu
Jan 1, 1971·International Review of Neurobiology·A R Lieberman
Dec 1, 1965·J R Microsc Soc·S O Ebbesson, D Tang
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·H Teräväinen
Jan 15, 1980·The Journal of Comparative Neurology·J M Kerns
Oct 1, 1990·The European Journal of Neuroscience·P. A. EcclestonW. D. Richardson
Jan 1, 1989·The European Journal of Neuroscience·E R LunnS Gordon
Jan 1, 1991·The European Journal of Neuroscience·M C BrownV H Perry
Oct 1, 1956·Physiological Reviews·W F WINDLE
Aug 22, 1904·The Journal of Physiology·J N Langley, H K Anderson
Feb 1, 1946·The Anatomical Record·M ABERCROMBIE

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