PMID: 8448126Mar 16, 1993Paper

Regeneration of bovine pancreatic ribonuclease A. 4. Temperature dependence of the regeneration rate

Biochemistry
D M Rothwarf, H A Scheraga

Abstract

The rate of regeneration of bovine pancreatic ribonuclease A with oxidized and reduced dithiothreitol (DTTox and DTTred, respectively) decreases by a factor of 10 when the temperature is increased from 25 to 37 degrees C. The rate of regeneration of RNase A with oxidized and reduced glutathione increases slightly over that same range of temperature. This suggests that the regeneration processes with the two types of redox reagents proceed through different pathways. There is a significant change in the distribution of three-disulfide intermediates populated during regeneration with DTTox/DTTred over the range of temperature 15-37 degrees C that suggests that the three-disulfide species populated at 15 degrees C are directly involved in the major regeneration pathway observed at 25 degrees C.

References

Apr 15, 1979·Journal of Molecular Biology·T E Creighton
Jun 25, 1977·Journal of Molecular Biology·T E Creighton
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D M Rothwarf, H A Scheraga
Aug 13, 1974·Biochemistry·R R HantganH A Scheraga
Jan 1, 1984·Advances in Biophysics·H A ScheragaT Ooi
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·Y KonishiH A Scheraga

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Citations

Apr 19, 2007·Biochemistry·Ervin WelkerHarold A Scheraga
Jun 1, 1995·Nature Structural Biology·Y J LiH A Scheraga
Dec 1, 1995·Nature Structural Biology·J S Weissman, P S Kim
Oct 24, 2002·European Journal of Biochemistry·Yong-Bin YanHai-Meng Zhou
Jul 1, 2008·Annual Review of Cell and Developmental Biology·Bharath S Mamathambika, James C Bardwell
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·E WelkerH A Scheraga
Nov 11, 1999·FEBS Letters·E WelkerH A Scheraga
May 19, 2012·The FEBS Journal·Mahesh Narayan
Apr 7, 2000·Protein Science : a Publication of the Protein Society·F VinciG Marino
Nov 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mahesh Narayan
Sep 26, 2017·Journal of Chemical Theory and Computation·Paweł KrupaHarold A Scheraga
Apr 12, 2000·Biochemistry·W J WedemeyerH A Scheraga

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