Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor)

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Takashi NishidaMasaharu Takigawa

Abstract

CTGF/CCN2, a hypertrophic chondrocyte-specific gene product, possessed the ability to repair damaged articular cartilage in two animal models, which were experimental osteoarthritis and full-thickness defects of articular cartilage. These findings suggest that CTGF/CCN2 may be useful in regeneration of articular cartilage. Connective tissue growth factor (CTGF)/CCN2 is a unique growth factor that stimulates the proliferation and differentiation, but not hypertrophy, of articular chondrocytes in vitro. The objective of this study was to investigate the therapeutic use of CTGF/CCN2. The effects of recombinant CTGF/CCN2 (rCTGF/CCN2) on repair of damaged cartilage were evaluated by using both the monoiodoacetic acid (MIA)-induced experimental rat osteoarthritis (OA) model and full-thickness defects of rat articular cartilage in vivo. In the MIA-induced OA model, quantitative real-time RT-PCR assays showed a significant increase in the level of CTGF/CCN2 mRNA, and immunohistochemical analysis and in situ hybridization revealed that the clustered chondrocytes, in which clustering indicates an attempt to repair the damaged cartilage, produced CTGF/CCN2. Therefore, CTGF/CCN2 was suspected to play critical roles in cartilage repair. In ...Continue Reading

References

May 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T NakaseK Takaoka
Apr 1, 1994·The Journal of Bone and Joint Surgery. American Volume·S WakitaniV M Goldberg
Apr 1, 1994·Japanese Journal of Cancer Research : Gann·J D ZhuM Takigawa
Apr 29, 1998·Kidney International·Y ItoR Goldschmeding
Jul 2, 1998·Biochemical and Biophysical Research Communications·T NishidaM Takigawa
Mar 30, 1999·Experimental Cell Research·L F Lau, S C Lam
Jul 9, 1999·Journal of Biomedical Materials Research·X Wei, K Messner
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·M YamamotoY Ikada
Sep 26, 2000·Molecular Genetics and Metabolism·E E Moussad, D R Brigstock
Jun 11, 2002·The British Journal of Oral & Maxillofacial Surgery·T SuzukiT Iizuka
Jan 28, 2003·Journal of Cellular Physiology·Masaharu TakigawaTakashi Nishida
Apr 1, 2003·Molecular Pathology : MP·D R BrigstockH Yeger

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Citations

Jun 7, 2014·Journal of Cell Communication and Signaling·Tarek Abd El KaderMasaharu Takigawa
May 16, 2008·Journal of Cell Communication and Signaling·Takashi NishidaKaren M Lyons
Oct 3, 2009·Journal of Cell Communication and Signaling·Kumi SumiyoshiMasaharu Takigawa
Apr 13, 2011·Journal of Cell Communication and Signaling·Satoshi Kubota, Masaharu Takigawa
May 15, 2013·Journal of Cell Communication and Signaling·Faith Hall-GlennKaren M Lyons
Jun 25, 2013·Journal of Cell Communication and Signaling·Masaharu Takigawa
Jan 4, 2008·Molecular and Cellular Biology·Takanori EguchiMasaharu Takigawa
Aug 23, 2011·Cellular and Molecular Life Sciences : CMLS·Faith Hall-Glenn, Karen M Lyons
Jan 18, 2013·Arthritis·Martin H GregorySeth L Sherman
Jul 28, 2009·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Natasa D MiljkovicKacey G Marra
Jul 31, 2013·The American Journal of Chinese Medicine·Alciléia Nunes YamadaRoberto Kenji Nakamura Cuman
Sep 15, 2015·Journal of Cellular Biochemistry·Yurika MuraseSatoshi Kubota
Jul 8, 2011·Injury·Javier Vaquero, Francisco Forriol
May 4, 2010·Biochimie·Harumi KawakiMasaharu Takigawa
Feb 7, 2008·Reproductive Biomedicine Online·Yasuhiko Tabata
Mar 15, 2015·The Tohoku Journal of Experimental Medicine·Qin LiuLi Zheng
May 6, 2008·Best Practice & Research. Clinical Rheumatology·Robert Dinser
May 18, 2007·Journal of Dermatological Science·Yu Kimura, Yasuhiko Tabata
Jul 4, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Harumi KawakiMasaharu Takigawa
Mar 5, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Dongrim SeolTae-Hong Lim
Sep 20, 2011·Journal of Cellular Physiology·Cordula Surmann-SchmittMichael Stock
Jul 16, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Dongrim SeolTae-Hong Lim
Jan 25, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xinhua LinPaul O Zamora
Aug 20, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Takashi NishidaMasaharu Takigawa
Oct 2, 2009·Journal of Cellular Physiology·Kazumi KawataMasaharu Takigawa
Nov 30, 2013·Journal of Cellular Biochemistry·Aya Maeda-UematsuMasaharu Takigawa
May 13, 2006·Biochemical and Biophysical Research Communications·Kazumi KawataMasaharu Takigawa
Jan 13, 2006·Biochemical and Biophysical Research Communications·Xiaohong ZhangTsuneo A Takahashi
May 31, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Jake BedoreCheryle A Séguin
Nov 3, 2012·Biochimie·Emilio Satoshi HaraTakuo Kuboki
Feb 19, 2016·Cell Biology International·Noreen LatiefSheikh Riazuddin
Dec 27, 2005·Drug Discovery Today·Yasuhiko Tabata
Apr 10, 2013·Matrix Biology : Journal of the International Society for Matrix Biology·Cassie M TranMakarand V Risbud
Sep 9, 2008·The International Journal of Biochemistry & Cell Biology·Chih-Chiun Chen, Lester F Lau
Dec 7, 2010·Biochimie·L KularC Martinerie

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