Regeneration of nerve crush injury using adipose-derived stem cells: A multimodal comparison

Muscle & Nerve
Mathias TrempDaniel Felix Kalbermatten

Abstract

To restore full function following nerve crush injuries is critical but challenging. In an attempt to develop a viable therapy, we evaluated the effect of rat adipose-derived stem cells (rASC) in 2 different settings of a sciatic crush injury model. In the first group, after 14 days of nerve crush injury, rASCs were injected distal to the lesion under ultrasound guidance. In the other group, alleviation of compression through clip removal (CR) was combined with epineural injection of rASCs. Gait analyses, MRI, gastrocnemius muscle weight ratio (MWR), and histomorphometry were performed for outcome analysis. CR combined with rASC injection resulted in less muscle atrophy, as evidenced by MWR. These findings are further supported by better functional and anatomical outcomes. Animals treated with CR and epineural stem cell injection showed enhanced anatomical and functional recovery. Muscle Nerve 58: 566-572, 2018.

References

Jan 1, 1990·Methods in Cell Biology·P K HoranS E Slezak
Jan 1, 1989·Plastic and Reconstructive Surgery·J R BainD A Hunter
Apr 29, 1999·Brain Pathology·R GoldH P Hartung
Jan 26, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·D F KalbermattenG Terenghi
Sep 13, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Paul K WallaceKatharine A Muirhead
Oct 16, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·P G di SummaD F Kalbermatten
Dec 9, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Aris SterodimasIvo Pitanguy
Oct 19, 2010·Progress in Neurobiology·Ronald DeumensGary A Brook
Mar 17, 2011·The Journal of the American Academy of Orthopaedic Surgeons·Jason R KangRanjan Gupta
Mar 15, 2011·Cell and Tissue Research·Daniel F KalbermattenMikael Wiberg
Oct 26, 2012·Cytotechnology·Patricia E EngelsDaniel F Kalbermatten
Jul 31, 2013·Hand Clinics·Ron M G MenorcaJohn C Elfar
May 6, 2014·Neuroscience Letters·Pietro G di SummaDaniel F Kalbermatten
Jan 17, 2016·Microsurgery·Frances M WalockoPaul S Cederna
Dec 3, 2016·Neural Regeneration Research·Zahir KızılayAli Yılmaz

❮ Previous
Next ❯

Citations

Feb 1, 2019·Expert Opinion on Biological Therapy·Sara Sayad-FathiArash Zaminy
Oct 19, 2020·Journal of Neuroscience Research·Sophie Charlotte RhodeTim Ruhl
Aug 18, 2020·Plastic and Reconstructive Surgery. Global Open·Riccardo SchweizerVijay S Gorantla
Aug 22, 2021·Stem Cell Reviews and Reports·Liangfu JiangXiaofeng Jia
Feb 3, 2022·Cellular and Molecular Neurobiology·Ana Carolina Correa de AssisRenato Nery Soriano

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Software Mentioned

GraphPad
Prism
ImageJ
MITK Diffusion

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Brain and Behavior
Elisabeth A KapposDaniel Felix Kalbermatten
Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes
Xinchun LiBiling Liang
Archives of Physical Medicine and Rehabilitation
G J HerbisonJ F Ditunno
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Ji-Ung Park, Sung-Tack Kwon
© 2022 Meta ULC. All rights reserved