PMID: 7536273May 1, 1995Paper

Regeneration of nitric oxide synthase-containing nerves after cavernous nerve neurotomy in the rat

The Journal of Urology
S CarrierTom F Lue

Abstract

In patients who recover erectile function after radical prostatectomy (with preservation of at least 1 neurovascular bundle), a recovery time of 6 to 18 months is not uncommon. As this is also the usual time required for regeneration of spinal nerves, we believe that regeneration of cavernous nerves, partially damaged inadvertently, may be responsible. In a rat model, we examined the long-term effect of unilateral and bilateral cavernous nerve transection on the nonadrenergic/noncholinergic (NANC) nervous system and erectile function. In 31 rats, nitric oxide synthase (NOS), the enzyme that catalyzes nitric oxide production, was identified in penile nerve fibers from a mid-shaft segment with nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase staining and antibody to neuronal NOS. Animals were divided into three groups: 5 rats underwent pelvic exploration without transection of cavernous nerves (sham group); 13 rats underwent unilateral neurotomy of a 5-mm. segment of the cavernous nerve; and 13 rats underwent bilateral neurotomy. After bilateral ablation, the NOS-positive nerve fibers were significantly decreased at 3 weeks and remained so at 6 months; no erectile response could be elicited by pelvic nerve stimulati...Continue Reading

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Citations

Jan 5, 2002·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·T F Lue
May 4, 2005·Pharmacology & Therapeutics·Noboru TodaTomio Okamura
Jan 20, 2009·Asian Journal of Andrology·Xie-Gang DingYi Luo
Jul 28, 2007·International Journal of Impotence Research·B L Dalkin, B A Christopher
Jul 27, 2011·Therapeutic Advances in Urology·Robert Segal, Arthur L Burnett
Dec 4, 2012·Therapeutic Advances in Urology·Manuela TutoloFrancesco Montorsi
Mar 1, 2014·Current Urology Reports·Tariq S HakkyRafael E Carrion
Dec 11, 2007·Canadian Journal of Physiology and Pharmacology·Banafsheh AfsharimaniAhmad R Dehpour
Dec 23, 2015·Expert Opinion on Drug Discovery·Christopher Wu, Jason R Kovac
Jan 11, 2013·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Su Jin KimSae Woong Kim
May 10, 2006·The Journal of Sexual Medicine·Linda VignozziMario Maggi
Sep 1, 2003·Expert Review of Neurotherapeutics·Garrett H Lischer, Ajay Nehra
Jun 19, 2008·The Journal of Sexual Medicine·Neal MehtaMahadevan Rajasekaran
Sep 9, 2008·The Journal of Sexual Medicine·Onder Canguven, Arthur Burnett
Apr 19, 2000·Journal of Neurobiology·A LaurikainenM Saarma
Jun 22, 1999·International Journal of Urology : Official Journal of the Japanese Urological Association·M M BaşarA Atan
Jul 15, 2015·Therapeutic Advances in Urology·Ateş KadıoğluGerald Brock
May 20, 2016·Investigative and Clinical Urology·Yuji HottaKazunori Kimura
Jan 1, 1997·The Journal of Urology·A L Burnett
Nov 26, 2002·The British Journal of Surgery·I Lindsey, N J McC Mortensen
Dec 21, 2002·International Journal of Impotence Research·S F SezenA L Burnett
Aug 2, 2014·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Stanley A Skinner
Feb 25, 2020·The Journal of Comparative Neurology·Leopold PurkartMichael Brecht

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