PMID: 9541226Apr 16, 1998Paper

Regeneration of periodontal ligament and cementum by BMP-applied tissue engineering

European Journal of Oral Sciences
Y KubokiH Kato

Abstract

Previously, we demonstrated that the inductive properties of bone morphogenetic protein (BMP) highly depend on the nature of the carrier material used for implantation. In this paper, we show that administration of BMP incorporated in a fibrous collagen membrane can help to regenerate periodontal ligament and cementum both in cat canines and in monkey molars. The partially purified bovine BMP was combined with one or two layers of a fibrous collagen membrane. Although the single layer approach showed partial regeneration of periodontal defects, it also quite often led to ankylosis. The double layer technique in artificially prepared class III furcation defects in monkey molars gave favorable results. After 12 wk, not only the alveolar process but also the periodontal ligament and cementum had regenerated along the entire treated dentin surface. Collagen fibers were arranged more or less perpendicular to the surface of the new cementum. Ankylosis was not seen. It is concluded that the double-layer approach is superior to the single-layer technique in regenerating cementum.

Citations

Jul 9, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Zhonggang FengMitsuo Umezu
Sep 24, 2010·Journal of Periodontal Research·S KhedmatS N Ostad
Jul 11, 2012·Journal of Tissue Engineering and Regenerative Medicine·R P Félix LanaoJ A Jansen
Dec 17, 2014·Periodontology 2000·Higinio ArzateGabriela Mercado-Celis
Jan 27, 2015·Orthodontics & Craniofacial Research·M AlsulaimaniC Flores-Mir
Dec 5, 2000·The Journal of the American Dental Association·R A Freitas
Nov 2, 2004·Journal of Periodontology·Hiroyuki KawaguchiHidemi Kurihara
Jan 21, 2006·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Malka Ashkenazi, Ilanit Shaked
Sep 3, 2004·Journal of Periodontology·Tae-Il KimYoung Ku
Sep 26, 2002·Journal of Periodontology·Knut A SelvigUlf M E Wikesjö
Aug 9, 2002·The Journal of International Medical Research·K KusumotoY Ogawa
Aug 18, 2004·Journal of Clinical Periodontology·Rachel G SorensenJohn M Wozney
Sep 6, 2000·Journal of Periodontology·A M HoangD L Cochran
Sep 27, 2003·Tissue Engineering·Yasuhiko Tabata
May 12, 2006·Periodontology 2000·Tanida SrisuwanKeren M Abberton
Apr 28, 2005·Journal of Periodontal Research·Ryohko HaraAkio Tanaka
Jul 31, 2003·Journal of Clinical Periodontology·Ulf M E WikesjöW Ross Hardwick
Jul 31, 2003·Journal of Clinical Periodontology·Ulf M E WikesjöW Ross Hardwick
Jun 6, 2019·Clinical Oral Investigations·Oliver LaugischAnton Sculean
Jan 25, 2008·The Journal of Craniofacial Surgery·André de Mendonça CostaMaria Rita Passos-Bueno

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