Regeneration of sensory but not motor axons following visceral nerve injury

Experimental Neurology
Sophie C PayneJ R Keast

Abstract

Following peripheral nerve injury, restoration of function may occur via the regeneration of injured axons or compensatory sprouting of spared axons. Injury to visceral nerves that control urogenital organs is a common consequence of pelvic surgery, however their capacity to reinnervate organs is poorly understood. To determine if and how sensory and motor connections to the bladder are re-established, a novel surgical model of visceral nerve injury was performed unilaterally in adult male Wistar rats. Bladder-projecting motor and sensory neurons in pelvic ganglia and lumbosacral dorsal root ganglia, respectively, were identified and characterised by retrograde tracing and immunofluorescence. Application of tracers ipsi- and contralateral to injury distinguished the projection pathways of new connections in the bladder. In naive animals, the majority of sensory and motor neurons project ipsilaterally to the bladder, while ~20 % project contralaterally and ~5 % bilaterally. Injured axons of motor neurons were unable to regenerate by 4weeks after transection. In contrast, by this time many injured sensory neurons regrew axons to reform a substantial plexus within the detrusor and suburothelial tissues. These regeneration response...Continue Reading

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Citations

Nov 8, 2016·Neuroscience Letters·Menghon CheahBarbara Haenzi
Dec 9, 2017·Journal of Neural Engineering·Jesse P SomannPedro P Irazoqui
Jan 27, 2017·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Jeová Nina Rocha
Jan 24, 2017·Frontiers in Neuroscience·K Elaine Ritter, E Michelle Southard-Smith
May 18, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Youko Ikeda
Jul 3, 2021·International Journal of Molecular Sciences·K Elaine RitterE Michelle Southard-Smith

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