Regeneration of specific innervation in Xenopus pectoralis muscle

Journal of Neurobiology
Y Harada, A D Grinnell

Abstract

We investigated the motor unit organization and precision of reinnervation in the Xenopus pectoralis muscle following different manipulations, including crush or section of the posterior pectoralis nerve, foreign nerve innervation, and crush coupled with activity modulation or block. Most fibers have two neuromuscular junctions, and multielectrode recordings were used to identify the axonal origin of all inputs to both junctions on most or all fibers covering about 25% of the muscle surface. Following simple nerve crush, a highly organized innervation pattern was restored, indistinguishable from the normal pattern, including selective innervation of fibers of similar input resistance (R(in)), compact motor unit organization, and high incidence of exclusive innervation of both end plates on each fiber by the same axon (distributed mononeuronal innervation, or a/a pattern). Initial reinnervation was equally precise when nerve conduction in the regenerating nerve was blocked by tetrodotoxin. More distant or repeated nerve crush or nerve section delayed and reduced the precision of reinnervation, but the majority of fibers still received input to both end plates by the same axon, often in combination with others. A foreign nerve, t...Continue Reading

References

Jan 1, 1978·The Journal of Physiology·M J Dennis, J W Yip
Dec 1, 1976·Journal of Neurocytology·M S LetinskyU J McMahan
Nov 1, 1990·The Journal of Comparative Neurology·A W English
Jan 1, 1990·Journal of Neurobiology·A A Herrera, M J Werle
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J Covault, J R Sanes
Mar 25, 1985·Brain Research·B Nudell, A D Grinnell
Dec 1, 1971·The Journal of Experimental Zoology·L M Grimm
Oct 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·N HolderP Jesani
May 1, 1982·The Journal of Physiology·N HolderD A Tonge
Feb 1, 1995·Current Opinion in Neurobiology·K S Cramer, M Sur
Mar 1, 1995·Journal of Neurobiology·P DohertyF S Walsh
Jan 1, 1995·Neuron·Y J Son, W J Thompson
Jul 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A J Scheetz, M Constantine-Paton
Sep 1, 1993·The Journal of Physiology·R Dunia, A A Herrera
Mar 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S M Gatesy, A W English

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