PMID: 9548263Apr 21, 1998Paper

Regeneration of the hepatic nerves following surgical denervation of the liver in dogs

Liver
Y ItoK Akira

Abstract

This study was conducted to examine the regeneration process of hepatic nerves following surgical hepatic denervation in dogs. A denervation model was surgically created by removing all visible nerves around the hepatoduodenal ligament along with the peri-hepatic tissues. The hepatic nerves were examined on the hepatic specimens taken at 1 week, 1 month and 3 months post-denervation by means of immunohistochemical staining, and also electron microscopy. At 1 week post-denervation, the extrinsic hepatic nerves were observed not to have regenerated. However, at 1 month post-denervation, GAP-43-positive nerves were identified and regenerating axons were shown to be present on electron microscopic observation. The immunoreactivity for anti-GAP-43 antibody was not shown any longer at 3 months post-denervation, and the regenerated nerve axons were shown to be similar to those at pre-denervation on ultrastructural study. Results of the present study suggested that regeneration of the extrinsic hepatic nerves began to appear about 1 month after the hepatic denervation, and was completed by 3 months post-denervation.

References

Jul 1, 1977·The Journal of Cell Biology·W G Forssmann, S Ito
May 1, 1978·The Anatomical Record·F D ReillyR S McCuskey
Jun 1, 1992·The Journal of Pathology·A P DhillonP J Scheuer
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Jan 1, 1983·Progress in Neurobiology·W W Lautt

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Citations

Aug 18, 2005·American Journal of Physiology. Endocrinology and Metabolism·Catherine A DicostanzoAlan D Cherrington
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Isabelle ColleBernard De Hemptinne

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