Regeneration of the periodontium using enamel matrix derivative in combination with an injectable bone cement.

Clinical Oral Investigations
Daniël A W OortgiesenJohn A Jansen

Abstract

Enamel matrix derivative (EMD) has proven to enhance periodontal regeneration; however, its effect is mainly restricted to the soft periodontal tissues. Therefore, to stimulate not only the soft tissues, but also the hard tissues, in this study EMD is combined with an injectable calcium phosphate cement (CaP; bone graft material). The aim was to evaluate histologically the healing of a macroporous CaP in combination with EMD. Intrabony, three-wall periodontal defects (2 × 2 × 1.7 mm) were created mesial of the first upper molar in 15 rats (30 defects). Defects were randomly treated according to one of the three following strategies: EMD, calcium phosphate cement and EMD, or left empty. The animals were killed after 12 weeks, and retrieved samples were processed for histology and histomorphometry. Empty defects showed a reparative type of healing without periodontal ligament or bone regeneration. As measured with on a histological grading scale for periodontal regeneration, the experimental groups (EMD and CaP/EMD) scored equally, both threefold higher compared with empty defects. However, most bone formation was measured in the CaP/EMD group; addition of CAP to EMD significantly enhanced bone formation with 50 % compared with E...Continue Reading

References

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Citations

Oct 31, 2013·Journal of Tissue Engineering and Regenerative Medicine·Hongbing LiaoJohn A Jansen
Jul 16, 2015·Clinical Oral Investigations·Yufeng ZhangRichard J Miron
Nov 6, 2018·Current Stem Cell Research & Therapy·Dilcele Silva Moreira DziedzicKatherine Athayde Teixeira de Carvalho
Aug 24, 2017·Journal of Tissue Engineering and Regenerative Medicine·Pedro S BaboX Frank Walboomers
Jan 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingou LiangLei Cheng
Oct 30, 2020·Frontiers in Bioengineering and Biotechnology·Basmah El-SayedReem El-Gendy
Mar 9, 2021·Frontiers in Bioengineering and Biotechnology·Elisa MazzoniFernanda Martini
Sep 29, 2020·Journal of Oral Biology and Craniofacial Research·Aya Anwar AlsherifDoaa Ameen Taiema

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