PMID: 2489664Dec 1, 1989Paper

Regeneration of the rat submandibular glands after duct ligation

Kanagawa shigaku. The Journal of the Kanagawa Odontological Society
M Minabe

Abstract

The cytomorphologic changes associated with acinar cell recovery in the rat submandibular glands were examined by light and electron microscopic observation and immunohistochemical test using anti-bromodeoxyuridine antibody. Ligation of excretory ducts caused morphological disorganization of the gland parenchyma, with resultant disappearance of the acini, dilation of the ducts, pronounced fibrosis and infiltration of the inflammatory cells. At seven days after obstruction, the acinar cells shrunk and destroyed partly. However, the intercalated duct cells and the myoepithelial cells were unaffected by ligation. Immunohistochemically, bromodeoxyuridine (BrdU) labeled cells existed scatteringly in the original ducts through the period of duct ligation and unligation studied. In the glands after recanalization following 7 days of the duct ligation, the duct-like structures were recognized a progressive increase. There structures were significantly developed in number from 7 to 14 days after the unligation. However, the BrdU-containing nuclei were not almost found in the duct-like structures. At twenty one days after the removal of the obstruction, the regeneration of acinar cells was striking. At 28 days, the acini were almost norm...Continue Reading

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