PMID: 6164440Apr 6, 1981Paper

Regeneration of the septohippocampal pathways in adult rats is promoted by utilizing embryonic hippocampal implants as bridges

Brain Research
L F KromerU Stenevi

Abstract

The ability of embryonic hippocampal tissue to promote regeneration of cholinergic axons in the septohippocampal system has been studied in adult rats. Strips of embryonic hippocampus, taken from 7-40 mm rat fetuses, were implanted into a 2-3 mm wide cavity which completely transected the septal cholinergic axons innervating the intrinsic hippocampus. The ingrowth of cholinergic fibres into the denervated host hippocampal formation was monitored by measuring the activity of the enzyme, choline acetyltransferase (ChAT), and by acetylcholine esterase (AChE) histochemistry. The results demonstrated a gradual, partial return of both ChAT enzyme activity and AChE-positive fibres in the initially denervated hippocampal formation of the adult recipient. Time-course studies indicated that this ingrowth progressed from the implant into the rostral tip of the host hippocampus, and continued caudally to cover the entire dorsal hippocampus by 3-6 months postoperative. Although the regenerating AChE-positive fibres reached the hippocampal target in the recipient along abnormal routes, they reinnervated selectively the appropriate terminal areas within the host hippocampus and dentate gyrus, suggesting the presence of quite specific mechanis...Continue Reading

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Citations

Jan 22, 1986·Brain Research·D P KimbleG Stickrod
Jul 19, 1991·Brain Research·G BuzsákiF H Gage
May 13, 1996·Brain Research·W P NgA Lozano
May 1, 1990·Journal of Neuroscience Methods·C T Montgomery, J A Robson
Nov 1, 1983·Brain Research·P J ReierL Guth
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Jan 1, 1989·Brain Research Bulletin·G H Collins, N R West
Oct 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A R HarveyM W Beilharz
Dec 1, 1996·Progress in Neurobiology·A K Shetty, D A Turner

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