Regeneration of the tympanic membrane using fibroblast growth factor-2

The Journal of Laryngology and Otology
Z-C LouJ Xiao

Abstract

A systematic review was conducted to investigate the effectiveness of fibroblast growth factor-2 on the regeneration of tympanic membrane perforation. The PubMed database was searched for relevant studies. Experimental studies, human randomised controlled trials, prospective single-arm studies and retrospective studies reporting acute and chronic tympanic membrane perforations in relation to two healing outcomes (success rate and closure time), were selected. All 11 clinical studies investigating the effect of fibroblast growth factor-2 on traumatic tympanic membrane perforations in humans reported a success rate of 89.3-100 per cent, with a closure time of around 2 weeks. Three studies of fibroblast growth factor-2 combined with Gelfoam showed that the success rate of chronic tympanic membrane perforation was 83-98.1 per cent in the fibroblast growth factor-2 group, but 10 per cent in the gelatine sponge groups. Fibroblast growth factor-2 with or without biological material patching promotes regeneration in cases of acute and chronic tympanic membrane perforation, and is safe and efficient. However, the best dosage, application time and administration pathway of fibroblast growth factor-2 are still to be elucidated.

References

Mar 1, 1992·American Journal of Surgery·P HaywardM Robson
Apr 1, 1991·Journal of Pediatric Surgery·P J HennesseyR J Andrassy
Jan 1, 1991·The Journal of Surgical Research·B D StenbergM C Robson
Apr 1, 1989·British Medical Bulletin·A Baird, P A Walicke
Jul 1, 1989·The Journal of Cell Biology·D B Rifkin, D Moscatelli
Jan 1, 1989·Annual Review of Biochemistry·W H Burgess, T Maciag
Aug 1, 1989·The Journal of Clinical Investigation·S E LynchH N Antoniades
Sep 1, 1994·American Journal of Otolaryngology·M Mondain, A Ryan
Dec 1, 1996·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M Kato, R K Jackler
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Y OzkaptanS Deveci
Jan 7, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S A GoldmanS P Cass
Jul 2, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·K ChauvinC Parkins
Oct 23, 2002·The Annals of Otology, Rhinology, and Laryngology·Shin-ichi Ishimoto, Toshio Ishibashi
Mar 27, 2003·Neurosurgery·Tetsuji SekiyaShigeharu Suzuki
Mar 25, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Kei-Ichi KaseHaruo Takahashi
Nov 27, 2009·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Nobuhiro HakubaTadahiko Wada
Sep 9, 2010·The Laryngoscope·Peter Luke Santa MariaReza Ghassemifar
Mar 25, 2011·The Laryngoscope·Anders Niklasson, Krister Tano
Sep 8, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Shin-Ichi KanemaruJuichi Ito
Sep 14, 2012·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Q Zhang, Z Lou
Sep 25, 2012·Exercise and Sport Sciences Reviews·William E Kraus, Mahesh J Patel
Nov 15, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Zhengcai Lou
Jun 5, 2013·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Z-C Lou, Y-B-Z Wang
Aug 10, 2013·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·N HakubaK Gyo
Feb 13, 2014·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Nobuhiro HakubaKiyofumi Gyo
Jan 27, 2015·International Journal of Pediatric Otorhinolaryngology·Aanand N AcharyaGunesh P Rajan
Jun 16, 2015·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Peter Luke Santa MariaYunzhi Peter Yang
Mar 10, 2016·American Journal of Otolaryngology·Zhengcai LouJiang Chang
Jun 15, 2016·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Zheng-Cai LouJiang Chang

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Citations

Feb 26, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Juntao HuangYi Shen
Jul 15, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Xu YaoYi Shen
May 1, 2020·BMJ : British Medical Journal·Michael J McPhailDavid G Lott
Nov 10, 2020·Tissue Engineering. Part B, Reviews·Mina AleemardaniAlexander Seifalian
May 26, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Shan XuNing Yang

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