Regeneration of tooth-like hydroxyapatite depended on amelogenin functional section monolayer: a new approach for tooth repair

Medical Hypotheses
Kun TianWei Fei

Abstract

Tooth defect due to caries, trauma, or acid corrosion are common in mankind. Ceramics, metal and resin were used to repaired tooth defect in the past hundred years, but they cannot instead enamel and dentin in depth in clinic usage for the difference in structure and element. So the formation of organized nanocrystals that resemble enamel is crucial for successful enamel remineralization. Now synthesizing a mimicking structure of human enamel using acellular methods has attracted much interest from research groups who have tried using recombinant enamel making proteins like amelogenin, surfactants, to mimic the biomineralization process to restore the enamel layer. Since amelogenin can be used in the assembly of functional nanostructures, we hypothesis that rationally designed β-sheet-forming peptides that spontaneously form three-dimensional fibrillar scaffolds in response to specific environmental triggers may potentially be used in inducing tooth-like hydroxyapatite crystal ex vivo which important to treatment/prevention of dental caries, via bioactive surface groups.

References

Mar 1, 1994·Journal of Structural Biology·A G FinchamH C Slavkin
May 29, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C E Smith
Dec 20, 2002·Connective Tissue Research·James P Simmer, Jan C C Hu
Mar 5, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Zhaoping LiuYitai Qian
Jun 2, 2005·Journal of Colloid and Interface Science·Haifeng ChenJohn F Mansfield
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Nov 11, 2008·Biomaterials·Yuwei FanJanet Moradian-Oldak
Aug 11, 2010·The Journal of Physical Chemistry. B·Alexander K BuellChristopher M Dobson

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Citations

Apr 30, 2021·Brazilian Dental Journal·Guilherme Genovez-JúniorRicardo Danil Guiraldo
Jun 11, 2021·International Journal of Biological Macromolecules·Zehui FangChris Ying Cao

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