Regenerative medicine: Antagonic-Stress therapy in distress and aging. I. Preclinical synthesis--2003

Annals of the New York Academy of Sciences
D RigaF Schneider

Abstract

Repetitive and cumulative distress (acute and/or chronic, psychic and/or biologic) and aging processes (impairment phenomena, agglomerated, and accumulated with the passing of life and senescence periods), as well as distress <==> aging reciprocal amplification-accelerating-aggravation relationships require strong and rational (etiopathogenic) therapeutic interventions. Therefore, the drug, Antagonic-Stress (AS)--a new integrative therapy, with specific synergistic formula, being patented worldwide--becomes an important solution in distress, senescence, and their related pathologies. In acute (contention) stress, AS treatment significantly decreased rat mortality, number and surface of stomach ulcerations, nonesterified fatty acids (NEFAs), and increased superoxide dismutase (SOD) from blood. In chronic psychic stress, live nerve cells selectively isolated from rat cerebral cortex were highly protected by the administration of AS. In addition, antistress and antiaging homeostatic actions of AS were demonstrated in accelerated senescence (aging + distress) at multiple brain levels: on functional anabolism [increase in total ribonucleic acids (RNA), total proteins (TP), and water-soluble proteins (WSP)]; on functional catabolism ...Continue Reading

Citations

Jun 29, 2006·Annals of the New York Academy of Sciences·Dan RigaFrancisc Schneider
May 14, 2010·Anais Brasileiros De Dermatologia·Milton Luiz Gorzoni, Sueli Luciano Pires

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