Regenerative Medicine Applications of Mesenchymal Stem Cells

Advances in Experimental Medicine and Biology
Samaneh HosseiniMohamadreza Baghaban Eslaminejad

Abstract

A major research challenge is to develop therapeutics that assist with healing damaged tissues and organs because the human body has limited ability to restore the majority of these tissues and organs to their original state. Tissue engineering (TE) and regenerative medicine (RM) promises to offer efficient therapeutic biological strategies that use mesenchymal stem cells (MSCs). MSCs possess the capability for self-renewal, multilineage differentiation, and immunomodulatory properties that make them attractive for clinical applications. They have been extensively investigated in numerous preclinical and clinical settings in an attempt to overcome their challenges and promote tissue regeneration and repair. This review explores the exciting opportunities afforded by MSCs, their desirable properties as cellular therapeutics in RM, and implicates their potential use in clinical practice. Here, we attempt to identify challenges and issues that determine the clinical efficacy of MSCs as treatment for skeletal and non-skeletal tissues.

Citations

Jul 28, 2019·Experimental Dermatology·Shadi KhalilArturo P Saavedra
Apr 14, 2020·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Mustafa Gökhan ErtosunÖmer Özkan
Feb 26, 2020·Epigenomics·Javid Sadri NahandMichael R Hamblin
Sep 13, 2020·Cell Communication and Signaling : CCS·Kasra AsgarpourHamed Mirzaei
Feb 16, 2019·Stem Cells International·Quan ZhuangYingzi Ming
Sep 16, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Carlota Tosat-Bitrián, Valle Palomo
Oct 30, 2020·Stem Cell Research & Therapy·Mahsa GhorbaninejadMohamadreza Baghaban Eslaminejad
Jun 3, 2021·Bioengineering·Christos KyriakidisElena García-Gareta

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