Regenerative medicine therapy for single ventricle congenital heart disease

Translational Pediatrics
Chetan AmbasthaSunjay Kaushal

Abstract

One of the most complex forms of congenital heart disease (CHD) involving single ventricle physiology is hypoplastic left heart syndrome (HLHS), characterized by underdevelopment of the left ventricle (LV), mitral and aortic valves, and narrowing of the ascending aorta. The underdeveloped LV is incapable of providing long-term systemic flow, and if left untreated, the condition is fatal. Current treatment for this condition consists of three consecutive staged palliative operations: the first is conducted within the first few weeks of birth, the second between 4 to 6 months, and the third and final surgery within the first 4 years. At the conclusion of the third surgery, systemic perfusion is provided by the right ventricle (RV), and deoxygenated blood flows passively to the pulmonary vasculature. Despite these palliative interventions, the RV, which is ill suited to provide long-term systemic perfusion, is prone to eventual failure. In the absence of satisfying curative treatments, stem cell therapy may represent one innovative approach to the management of RV dysfunction in HLHS patients. Several stem cell populations from different tissues (cardiac and non-cardiac), different age groups (adult- vs. neonate-derived), and diff...Continue Reading

Citations

Feb 19, 2020·Journal of the American Heart Association·Valeria Vincenza AlvinoPaolo Madeddu
Jun 13, 2021·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Mohamed Abdullah Sunjay Kaushal
Nov 11, 2020·Seminars in Thoracic and Cardiovascular Surgery·Marie VincentiUNKNOWN Wanek HLHS Consortium Clinical Pipeline

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