Regenerative medicine using adult neural stem cells: the potential for diabetes therapy and other pharmaceutical applications

Journal of Molecular Cell Biology
Tomoko Kuwabara, Makoto Asashima

Abstract

Neural stem cells (NSCs), which are responsible for continuous neurogenesis during the adult stage, are present in human adults. The typical neurogenic regions are the hippocampus and the subventricular zone; recent studies have revealed that NSCs also exist in the olfactory bulb. Olfactory bulb-derived neural stem cells (OB NSCs) have the potential to be used in therapeutic applications and can be easily harvested without harm to the patient. Through the combined influence of extrinsic cues and innate programming, adult neurogenesis is a finely regulated process occurring in a specialized cellular environment, a niche. Understanding the regulatory mechanisms of adult NSCs and their cellular niche is not only important to understand the physiological roles of neurogenesis in adulthood, but also to provide the knowledge necessary for developing new therapeutic applications using adult NSCs in other organs with similar regulatory environments. Diabetes is a devastating disease affecting more than 200 million people worldwide. Numerous diabetic patients suffer increased symptom severity after the onset, involving complications such as retinopathy and nephropathy. Therefore, the development of treatments for fundamental diabetes is...Continue Reading

References

Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J DragoP F Bartlett
Jan 1, 1988·Experimental Brain Research·A Mackay-SimM Kremer
Jan 1, 1995·Annual Review of Neuroscience·F H GageL J Fisher
Oct 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·P K ChongC M Scrimgeour
Jan 17, 1996·Annals of the New York Academy of Sciences·S HoyerE Martin
Jan 1, 1996·Neurobiology of Aging·S CraftA Alderson
May 9, 1998·Science·I Wickelgren
Dec 22, 1999·Neurology·A OttM M Breteler
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·M LiuD H Lowenstein
Feb 26, 2000·Science·F H Gage
Jan 6, 2001·Development, Growth & Differentiation·N MoriyaM Asashima
May 3, 2002·Nature·Hongjun SongFred H Gage
Aug 31, 2002·Endocrine Journal·Yasuo Terauchi, Takashi Kadowaki
Dec 6, 2002·Endocrine Reviews·Sue M Firth, Robert C Baxter
Jan 7, 2003·Genes & Development·Ariel A AvilionRobin Lovell-Badge
Aug 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kevin A D'Amour, Fred H Gage
Oct 11, 2003·Current Opinion in Genetics & Development·Koji Okabayashi, Makoto Asashima
Oct 11, 2003·Molecular and Cellular Neurosciences·Maria A I AbergPeter S Eriksson
Nov 12, 2003·Experimental Biology and Medicine·Takashi KadowakiRyozo Nagai
Jan 8, 2004·The Journal of Cell Biology·Jenny HsiehFred H Gage
Oct 21, 2004·Nature Neuroscience·A Denise R GarciaMichael V Sofroniew
Dec 18, 2004·Endocrinology·Joel F HabenerMelissa K Thomas
Mar 2, 2005·Chemical Senses·H Georg KuhnMichael Nilsson
Oct 28, 2005·Nature·Dieter-Chichung LieFred H Gage
Oct 19, 2006·Current Opinion in Cell Biology·Florian T Merkle, Arturo Alvarez-Buylla
Jan 9, 2007·Journal of Neuroscience Methods·Christine DictusChristel Herold-Mende
Jan 25, 2007·Differentiation; Research in Biological Diversity·Mio NakanishiMakoto Asashima
Jul 21, 2007·Acta Pharmacologica Sinica·Yin HuangDa-ru Lu
Sep 22, 2007·Psychoneuroendocrinology·Tom BrismarSten Andersson
Jan 29, 2008·Current Stem Cell Research & Therapy·Masahiko AbematsuKinichi Nakashima

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Citations

May 28, 2010·Journal of the History of Biology·Melinda Bonnie Fagan
May 16, 2013·Stem Cell Research & Therapy·Ryo HidakaTomoko Kuwabara
Mar 30, 2013·AJNR. American Journal of Neuroradiology·G SuffrediniL M Levy
Sep 19, 2012·Stem Cells International·Masanao MachidaTomoko Kuwabara
Oct 11, 2012·Stem Cells International·Sonia Martínez-HerreroAlfredo Martínez
May 22, 2016·Diabetologia·Éva A Csajbók, Gábor Tamás

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