Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure

American Journal of Physiology. Gastrointestinal and Liver Physiology
Kim Erlend MortensenArthur Revhaug

Abstract

After parenchymal loss, the liver regenerates restoring normal mass and metabolic function. Prevailing theories on triggering events leading to regeneration include humoral, metabolic, and flow-mediated mechanisms, the latter emphasizing the importance of shear stress mediated nitric oxide regulation. We aimed to investigate whether the grade of resection and hence the portal venous pressure and sinusoidal shear stress increase would be reflected in the gene expression profiles in the liver remnant by using a global porcine cDNA microarray chip with approximately 23,000 genes represented. Six pig livers were resected with 62% (low portal pressure resection) and 75% (high portal pressure resection), resulting in a portal venous pressure increase from a baseline of 6.1-8.2 and 12 mmHg, respectively. By sampling consecutive biopsies from the liver remnants, we found differentially expressed genes in the high portal pressure resection group to have functions related primarily to apoptosis, nitric oxide metabolism and oxidative stress, whereas differentially expressed genes in the low portal pressure resection group potentially regulate the cell cycle. Common to both groups was the upregulation of genes regulating inflammation, tran...Continue Reading

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Citations

Feb 9, 2012·Langenbeck's Archives of Surgery·Kerstin AbshagenBrigitte Vollmar
Nov 21, 2012·Comparative Hepatology·Ingvild E NygårdArthur Revhaug
Feb 12, 2010·Comparative Hepatology·Kim E MortensenArthur Revhaug
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Jan 16, 2010·Acta Medica (Hradec Králové)·David RychtrmocZuzana Cervinková

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