PMID: 1185809Oct 1, 1975Paper

Regenerative response of the rat tracheal epithelium after acute exposure to tobacco smoke: a quantitative study.

Journal of the National Cancer Institute
A B Wells, L F Lamerton

Abstract

The regenerative response of the rat tracheobronchial epithelium after acute exposure to tobacco smoke was studied. Cigarettes were smoked automatically, and the smoke was diluted with air before being inhaled by the animals. Twenty-four hours after the animals were subjected to tobacco smoke, and with vinblastine as a metaphase-arrest agent, a wave of cell proliferation occurred. The intensity of the response was related to the type of smoke (it was more severe for cigarette than cigar tobacco) and depended on the concentration of smoke, but the timing of the response after moderate exposure was constant. The wave of proliferation would appear to be a local response to cell loss or damage, though morphologically the observed changes were slight. With repeated daily exposure, some adaptation of the tissue was apparent, in that the wave of rapid cell reproduction did not recur, but this did not imply that there was no progression of effect with respect to other pathologic processes. The responses to tobacco smoke and sulfur dioxide were compared. Cell proliferation provided a useful and rapid test of certain irritant effects of different types of tobacco smoke, but it was essential that animals free of chronic respiratory diseas...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.