Regenerative surgical therapy for peri-implantitis using deproteinized bovine bone mineral with 10% collagen, enamel matrix derivative and Doxycycline-A prospective 3-year cohort study

Clinical Oral Implants Research
Faustino MercadoSaso Ivanovski

Abstract

There is limited evidence regarding the long-term efficacy of regenerative treatment for peri-implantitis. The aim of this study was to evaluate a combination therapy of deproteinized bovine bone mineral with 10% collagen (DBBMC), enamel matrix derivative (EMD) and Doxycycline in the regeneration of bone defects associated with peri-implantitis. Thirty patients diagnosed with peri-implantitis (BoP/suppuration, probing depth greater than 4 mm, minimum radiographic bone loss of 20%, at least 2 years in function) were enrolled in the study. Clinical measurements included probing depths, recession, radiographic bone fill, gingival inflammation and bleeding on probing/suppuration. Following surgical access and debridement, the implant surfaces were decontaminated with 24% EDTA for 2 min, and the bone defects were filled with a combined mixture of DBBMC, EMD and Doxycycline powder. The defects were covered with connective tissue grafts where necessary. Clinical measurements were recorded after 12, 24 and 36 months. The mean probing depth and bone loss at the initial visit was 8.9 mm (±1.9) and 6.92 mm (±1.26), respectively. Both mean probing depth and bone loss reduced significantly from baseline to 3.55 mm (±0.50) and 2.85 mm (±0.73...Continue Reading

Associated Clinical Trials

Feb 24, 2021·Sıla Çağrı İşler

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Citations

Oct 18, 2018·Clinical Oral Implants Research·Mario RoccuzzoLisa J Heitz-Mayfield
Dec 16, 2018·International Journal of Molecular Sciences·Susanne JungSonja Sielker
Jun 18, 2020·International Journal of Implant Dentistry·Ahmad AghazadehStefan Renvert
Jan 26, 2021·IScience·João Gabriel Silva SouzaValentim Adelino Ricardo Barão
Jul 13, 2021·Acta Odontologica Scandinavica·Mehrnaz Beheshti Maal, Anders Verket
Oct 16, 2021·Clinical Implant Dentistry and Related Research·Iria González RegueiroJosé María Martínez-González

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