Regimen-related toxicity following reduced-intensity stem-cell transplantation (RIST): comparison between Seattle criteria and National Cancer Center Common Toxicity Criteria (NCI-CTC) version 2.0

Bone Marrow Transplantation
M SakiyamaTokyo SCT Consortium

Abstract

Acute regimen-related toxicity (RRT) is minimal in reduced-intensity stem-cell transplantation (RIST). However, the Seattle RRT grading (Bearman et al), developed in the context of conventional-intensity transplantation, is frequently applied to RIST. We compared the National Cancer Institute Common Toxicity Criteria (NCI-CTC) version 2.0 with the Seattle criteria after RIST in 86 patients. RRT within 30 days of transplant graded by both sets of criteria were significantly associated with the outcome confirming the predictive value of both the systems. A total of 15 patients died of disease progression, and 12 of transplant-related mortality: RRT (n = 2), graft-versus-host disease (GVHD) (n = 7), infection (n = 1), and others (n = 2). GVHD-related deaths primarily resulted from infections after steroid treatment (n = 6) and bronchiolitis obliterans (n = 1). This study shows that NCI-CTC is appropriate in toxicity evaluation of RIST, and that its application to RIST enables a toxicity comparison between RIST and other types of cancer treatments. Since GVHD is a significant problem in RIST, modifications are required to evaluate immunological complications following RIST.

References

Oct 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S I BearmanE D Thomas

❮ Previous
Next ❯

Citations

Jul 15, 2003·Pathology Oncology Research : POR·Olga EsikLajos Trón
May 17, 2007·Der Urologe. Ausg. A·H ReinhardN Graf
May 11, 2006·Cancer Chemotherapy and Pharmacology·Miguel Villalona-CaleroJohn Kuhn
Feb 14, 2008·Cancer Chemotherapy and Pharmacology·Geoffrey Y KuGary K Schwartz
Aug 11, 2010·Cancer Chemotherapy and Pharmacology·Athanasios G PallisVassilis Georgoulias
Dec 29, 2010·Cancer Chemotherapy and Pharmacology·Suzana StojanovicIva Kezic
Jan 29, 2005·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Barry V FortnerBrad S Stolshek
Dec 12, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·F RomitoV Mattioli
May 27, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Medine Caliskan Yilmaz, Suheyla A Ozsoy
Sep 4, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Agostino PaccagnellaCarlo Marchiori
Aug 10, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Elfriede R GreimelUNKNOWN Groupe d'Investigateurs Nationaux pour les Etudes des Cancers de l'Ovaire (GINECO)
Mar 3, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Linda T VahdatEdith A Perez
Apr 1, 2008·Journal of Gastroenterology·Yasuhiro FujinoYoshikazu Kuroda
Jun 13, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·André M MuradUNKNOWN Brazilian Gastric Cancer Study Group, Belo Horizonte, MG, Brazil
Apr 25, 2009·International Journal of Clinical Oncology·Satoshi OizumiUNKNOWN Hokkaido Lung Cancer Clinical Study Group
Oct 18, 2011·International Journal of Clinical Oncology·Yosuke HoritaYasuhiro Shimada
Sep 14, 2007·Breast Cancer Research and Treatment·August GarinSergey Tjulandin
Oct 29, 2008·Investigational New Drugs·Axel-R HanauskeAhmad Awada
Feb 10, 2009·Journal of Pharmacokinetics and Pharmacodynamics·Anthe S ZandvlietAlwin D R Huitema
Sep 9, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Eloá Pereira BraboNelson Spector
Dec 16, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R ColomerH Cortés-Funes
Feb 15, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·E E Habib, E S Fahmy
Apr 6, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C P CarmignaniP H Sugarbaker
Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·M L HernandoP A Lind
Nov 7, 2002·International Journal of Radiation Oncology, Biology, Physics·Subir NagJeffery M Fowler
Dec 31, 2003·International Journal of Radiation Oncology, Biology, Physics·Berrin OzturkMehmet Kitapci
Apr 21, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V CocquytB J Gertz
Jun 8, 2006·Bone Marrow Transplantation·M CavalierR P Nelson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.