Regio- and Stereoselective Cyanotriflation of Alkynes Using Aryl(cyano)iodonium Triflates

Journal of the American Chemical Society
Xi Wang, Armido Studer

Abstract

A novel, mild, and versatile approach for regioselective syn-addition of both the CN and OTf groups of aryl(cyano)iodonium triflates to alkynes is described. The reaction uses Fe-catalysis and can be conducted in gram scale. Products of the vicinal cyanotriflation can be stereospecifically readily further functionalized, rendering the method highly valuable.

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Citations

Mar 24, 2017·The Journal of Organic Chemistry·Eman ZawiaWesley J Moran
Jun 2, 2017·Organic Letters·Shicheng Shi, Michal Szostak
Jun 20, 2017·Chemistry : a European Journal·Xiaotao ZhuHongli Bao
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