Regio- and Stereoselective Radical Perfluoroalkyltriflation of Alkynes Using Phenyl(perfluoroalkyl)iodonium Triflates

Organic Letters
Xi Wang, Armido Studer

Abstract

A method for regio- and stereoselective anti-addition of the perfluoroalkyl and the triflate group of phenyl(perfluoroalkyl)iodonium triflates to alkynes is presented. The radical reaction uses cheap CuCl as a smart initiator and can be conducted in gram scale. The perfluoroalkyltriflated products are readily further functionalized, rendering this transformation valuable.

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Citations

Sep 1, 2018·Chemical Communications : Chem Comm·Min-Hua HuangBo Jiang
Jan 24, 2019·Chemical Communications : Chem Comm·Jinqiang KuangDaesung Lee
Apr 13, 2019·Chemistry : a European Journal·Athanasios MarkosPetr Beier
Jun 9, 2020·Chemistry, an Asian Journal·Jinkui ChaiNaohiko Yoshikai

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