Region- and Activity-Dependent Regulation of Extracellular Glutamate

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Nawrin F PinkyMatthew P Parsons

Abstract

Transporter-mediated glutamate uptake plays an essential role in shaping synaptic neurotransmission. The rapid removal of synaptically released glutamate ensures the high temporal dynamics characteristic of fast excitatory chemical neurotransmission and prevents the overexcitation of extrasynaptic NMDA receptors that have been implicated in synaptic plasticity impairments and cell death. Despite clear regional differences in plasticity and excitotoxic thresholds, few studies have compared extracellular glutamate dynamics across different brain regions and in response to a range of neural activity including plasticity-inducing stimuli. Here, we used the rapid extracellular fluorescent glutamate sensor iGluSnFR (intensity-based glutamate-sensing fluorescent reporter) and high-speed imaging (205 frames per second) to quantify relative differences in glutamate clearance rates over a wide range of presynaptic activity in situ in the hippocampus, cortex, and striatum of male C57/BL6NCrl mice. We found that the hippocampus was significantly more efficient than the cortex and striatum at clearing synaptically released glutamate and that this efficiency could be attributed, at least in part, to faster glutamate diffusion away from the r...Continue Reading

Citations

Nov 22, 2018·Frontiers in Cellular Neuroscience·Jenny B Koenig, Chris G Dulla
Mar 2, 2019·International Journal of Molecular Sciences·András Mihály
Aug 6, 2019·Frontiers in Cellular Neuroscience·Jade G Quirion, Matthew P Parsons
Aug 27, 2019·Frontiers in Cellular Neuroscience·Joana Gonçalves-RibeiroSandra Henriques Vaz
Apr 9, 2020·Frontiers in Cellular Neuroscience·Denisa Belov KirdajovaMiroslava Anderova
Apr 10, 2019·Communications Biology·Jennifer RomanosMirko Santello
Jul 31, 2019·Translational Research : the Journal of Laboratory and Clinical Medicine·Karen ScidaBrian G Jamieson
Feb 23, 2021·Journal of Neuroscience Research·Kyle J BrymerMatthew P Parsons
Feb 20, 2021·Frontiers in Cellular Neuroscience·Stefan PasslickChristian Henneberger
Jan 12, 2020·Communications Biology·Jennifer RomanosMirko Santello
Apr 13, 2021·Frontiers in Cellular Neuroscience·Crystal M WilkieMatthew P Parsons
Jun 27, 2021·Neuropharmacology·Dmitri A Rusakov, Michael G Stewart
Jul 17, 2021·Neural Regeneration Research·Mohammad UzairShahid Bashir
Jul 28, 2021·Neurochemistry International·Inês Belo do NascimentoEmmanuel Hermans
Jul 3, 2021·Journal of Cellular and Molecular Medicine·Jian LiuYu-Hong Wang
Aug 28, 2021·Frontiers in Pharmacology·Vojtech DvorakGiulio Superti-Furga

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