Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress

Neural Plasticity
Qiong WangWeiwen Wang

Abstract

Cognitive dysfunctions are highly comorbid with depression. Impairments of cognitive flexibility, which are modulated by the monoaminergic system of the prefrontal cortex (PFC), are increasingly recognized as an important component of the pathophysiology and treatment of depression. However, the downstream molecular mechanisms remain unclear. Using a classical model of depression, this study investigated the effects of social defeat stress on emotional behaviors, on cognitive flexibility in the attentional set-shifting task (AST), and on the expression of extracellular signal-regulated kinase 1 and 2 (ERK1 and ERK2) and their downstream signaling molecules cAMP-response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in two subregions of the PFC, the medial prefrontal cortex (mPFC), and the orbitofrontal cortex (OFC). The results showed that stress induced emotional and cognitive alterations associated with depression, including a decreased sucrose intake ratio and impaired reversal learning and set-shifting performance in the AST. Additionally, rats in the stress group showed a significant decrease only in ERK2 signaling in the mPFC, while more extensive decreases in both ERK1 signaling and ERK2 sig...Continue Reading

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Citations

May 23, 2020·Metabolic Brain Disease·Lu TianPeng Xie
Feb 23, 2020·International Journal of Molecular Sciences·Zhuang MiaoZhongsheng Sun
Nov 19, 2018·Neuropharmacology·Carmen Ferrer-PérezMarta Rodríguez-Arias
Apr 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Seul-Ki KimWon-Ki Kim

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Methods Mentioned

BETA
Protein Assay
transgenic

Software Mentioned

Statistical Package for Social Sciences ” ( SPSS
Lab Works TM

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