PMID: 9539803May 16, 1998Paper

Region-dependent dynamics of cAMP response element-binding protein phosphorylation in the basal ganglia

Proceedings of the National Academy of Sciences of the United States of America
F C Liu, A M Graybiel

Abstract

The cAMP response element-binding protein (CREB) is an activity-dependent transcription factor that is involved in neural plasticity. The kinetics of CREB phosphorylation have been suggested to be important for gene activation, with sustained phosphorylation being associated with downstream gene expression. If so, the duration of CREB phosphorylation might serve as an indicator for time-sensitive plastic changes in neurons. To screen for regions potentially involved in dopamine-mediated plasticity in the basal ganglia, we used organotypic slice cultures to study the patterns of dopamine- and calcium-mediated CREB phosphorylation in the major subdivisions of the striatum. Different durations of CREB phosphorylation were evoked in the dorsal and ventral striatum by activation of dopamine D1-class receptors. The same D1 stimulus elicited (i) transient phosphorylation (</=15 min) in the matrix of the dorsal striatum; (ii) sustained phosphorylation (</=2 hr) in limbic-related structures including striosomes, the nucleus accumbens, the fundus striati, and the bed nucleus of the stria terminalis; and (iii) prolonged phosphorylation (up to 4 hr or more) in cellular islands in the olfactory tubercle. Elevation of Ca2+ influx by stimulat...Continue Reading

References

Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P K DashE R Kandel
Jan 1, 1989·Annual Review of Psychology·R A Wise, P P Rompre
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·R MoratallaA M Graybiel
Oct 6, 1997·Science·E J Nestler, G K Aghajanian
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S A Bayer

❮ Previous
Next ❯

Citations

May 21, 2010·The Journal of Biological Chemistry·Michael W FriedrichOliver Griesbeck
Aug 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anjali RajadhyakshaBarry E Kosofsky
Oct 28, 2008·Behavioural Brain Research·Michael X Cohen, Michael J Frank
May 5, 2007·Neurobiology of Aging·Yves PorteNicole Mons
Jan 20, 2007·Molecular Pharmacology·Guo-Chi ZhangJohn Q Wang
Jun 28, 2019·Journal of Neurochemistry·Giuseppe GangarossaEmmanuel Valjent

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.