PMID: 7661361Sep 1, 1995

Region of epidural blockade determines sympathetic and mesenteric capacitance effects in rabbits

Anesthesiology
Q H HoganJ P Kampine

Abstract

The mechanisms producing hemodynamic changes during epidural anesthesia are incompletely understood. The role of capacitance changes in the splanchnic venous bed can be clarified by comparing blocks of differing segmental distributions. Specifically, we speculated that blocks that include the innervation to the mesenteric circulation alter hemodynamics, sympathetic activity, and venous capacitance to a greater extent than blocks without blockade of sympathetic nerves to this critical vascular bed. Rabbits were studied during alpha-chloralose anesthesia and mechanical ventilation. Sympathetic efferent nerve activity to the mesenteric vessels was measured by surgically placed electrodes, and mesenteric vein diameter was measured by videomicroscopy. Heart rate and mean arterial pressure were monitored by intraarterial cannulation. Responses were compared after administration of epidural lidocaine using a dose and catheter level that limited anesthetic to lumbar levels (lumbar group) or thoracic levels (thoracic group). In addition, hemodynamic responses were recorded after thoracolumbar block in animals receiving alpha-chloralose but breathing spontaneously (spontaneous ventilation group) and in awake animals (awake group). Mean a...Continue Reading

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Related Concepts

Arterial Pulse Pressure
Nervousness
Microscopy, Video
Splanchnic Circulation
Adrenergic Fibers
Sympathetic Nervous System
Hypokinesia
Entire Vein
Muscle Innervation, Function
Body Parts - Epidural

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