Region-specific astrogliosis: differential vessel formation contributes to different patterns of astrogliosis in the cortex and striatum.

Molecular Brain
Haijie YangEun-Hye Joe

Abstract

Brain injury causes astrocytes to become reactive (astrogliosis). In this study, we compared astrogliosis in acutely injured cortex and striatum of adult FVB/N mice induced by stereotaxic injection of ATP, a component of danger-associated molecular patterns (DAMPs). Interestingly, MR analysis showed that same amount of ATP induced smaller damage in the cortex than in the striatum. However, in histological analysis, thick and dense scar-like astrogliosis was found in the injured cortex near meninges within 2 wk., but not in other regions, including the striatum and even the cortex near the corpus callosum for up to 30 d. There was little regional difference in the number of Ki67(+)-proliferating astrocytes or mRNA expression of inflammatory cytokines. The most prominent difference between regions with and without scar-like astrogliosis was blood vessel formation. Blood vessels highly expressing collagen 1A1 formed densely near meninges, and astrocytes converged on them. In other regions, however, both blood vessels and astrocytes were relatively evenly distributed. Consistent with this, inhibition of blood vessel formation with the vascular endothelial growth factor (VEGF)-blocking antibody, Avastin, attenuated scar-like astrogl...Continue Reading

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Citations

Aug 12, 2021·Experimental Neurobiology·Sung Eun LeeSun Ah Park
Oct 27, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jae-Kyung KwonEun-Hye Joe

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

Zen
PictureFrame Application
Imaris
MetaMorph Image Analysis
Mimics
MetaMorph

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