Region-specific effect of testosterone on oxytocin receptor binding in the brain of the aged rat

Brain Research
Y Arsenijevic, E Tribollet

Abstract

We reported previously a significant reduction of oxytocin (OT) receptor binding in the brain of 20-month old rats relative to 3-month old ones. The present study shows that testosterone treatment of aging rats restores normal adult levels of OT receptor binding in the olfactory tubercle and in the hypothalamic ventromedial nucleus, but not in the caudate-putamen. These data indicate that the reduced plasma testosterone found in 20-month old rats is responsible for the loss of OT receptors in the olfactory tubercle and hypothalamic ventromedial nucleus, whereas other aging-related mechanisms may account for the decrease of OT receptor binding in the caudate-putamen.

Citations

Nov 23, 2019·Journal of Neurochemistry·Hillary L CanslerDaniel W Wesson
Sep 26, 2013·Development and Psychopathology·Mark R DaddsRichard E Ebstein
Apr 16, 2016·Psychiatry Investigation·Veronika Marcincakova HusarovaDaniela Ostatnikova
Jun 14, 2018·Physiological Reviews·Benjamin Jurek, Inga D Neumann

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