Region-specific expression of the androgen receptor in the human epididymis

Molecular Human Reproduction
H UngefrorenS Ergün

Abstract

The expression of the androgen receptor in the human epididymis was analysed by ribonuclease protection, in-situ hybridization and immunohistochemistry. Androgen receptor mRNA and protein could be detected throughout the entire organ, albeit in different quantities, in the caput, corpus and cauda regions, respectively. Also positive, though only weakly, was the ductus deferens, while the efferent ducts were devoid of specific signals. In-situ transcript hybridization and immunocytochemistry localized androgen receptor mRNA and protein primarily to the epithelium of the epididymal duct. In the ductal epithelial cells androgen receptor immunoreactivity showed a distinct nuclear distribution. While peritubular cells occasionally displayed weak signals, interstitial cells as well as blood vessels were consistently negative throughout the entire organ. The observed pattern of androgen receptor expression in the human epididymis supports the notion that the structure and function of the epididymis is differentially controlled by androgens in a region-specific manner, whereas it would not seem compatible with a direct role for androgens in the regulation of epididymal blood flow.

Citations

Oct 12, 2010·Biology of Reproduction·Avenel JosephRex A Hess
Jun 26, 2007·Asian Journal of Andrology·Bernard RobaireSophie-Anne Lamour
Jul 20, 2012·General and Comparative Endocrinology·Renee ZayaChristopher A Pearl
Jan 26, 2011·Reproductive Toxicology·Daniela A Fossato da SilvaWilma De G Kempinas
Oct 31, 2006·The Journal of Urology·Kazutaka SaitoKazunori Kihara
Dec 30, 2014·Fertility and Sterility·Shih-Hsing LeirAnn Harris
Feb 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Marilia T C C PatrãoMaria Christina W Avellar
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Oct 22, 2013·Reproduction, Fertility, and Development·S Arrighi
May 3, 2019·Andrology·J A BrowneA Harris
Jan 15, 2021·Differentiation; Research in Biological Diversity·Rex A HessBarry T Hinton
Jan 12, 2021·Saudi Journal of Biological Sciences·Yasmine Asaad MansourGehad A H El-Bargeesy

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