Region-specific induction of FosB/ΔFosB by voluntary alcohol intake: effects of naltrexone.

Alcoholism, Clinical and Experimental Research
Jing LiJiang-Hong Ye

Abstract

ΔFosB is the best characterized transcription factor induced by chronic stimulation. Although previous studies have demonstrated that chronic passive ethanol exposure alters ΔFosB immunoreactivity (IR), the effect of chronic voluntary ethanol consumption on ΔFosB remains unknown. Furthermore, although previous studies have demonstrated that the opioid antagonist naltrexone reduces alcohol consumption in clinical and preclinical settings, the effect of naltrexone on FosB/ΔFosB has not been explored. Here, we examined the effects of chronic voluntary ethanol intake and naltrexone on FosB/ΔFosB IR in striatal region and prefrontal cortex, and the effect of naltrexone on voluntary ethanol intake. We utilized immunohistochemistry to define the changes in FosB/ΔFosB IR induced by chronic voluntary ethanol intake under a two-bottle intermittent access of 20% ethanol model and by systematic administration (intraperitoneal injection) of naltrexone in Sprague-Dawley rats. Chronic (15 drinking sessions in 35 days) voluntary ethanol intake robustly induces FosB/ΔFosB IR in nucleus accumbens core, dorsolateral striatum, and orbitofrontal cortex, but not in nucleus accumbens shell, dorsomedial striatum, and medial prefrontal cortex. Systemic...Continue Reading

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Citations

Jan 13, 2012·The Journal of Pharmacology and Experimental Therapeutics·Jing LiJiang-Hong Ye
Feb 22, 2014·Alcohol·Barbara LoiGian Luigi Gessa
Aug 2, 2014·Brain Structure & Function·T A RetsonE J Van Bockstaele
Apr 21, 2016·Brain Research Bulletin·Rosana Camarini, Ricardo Marcos Pautassi
May 29, 2016·The International Journal of Neuropsychopharmacology·Jing LiJiang Hong Ye
Dec 7, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Aranza Wille-BilleRicardo Marcos Pautassi
Apr 7, 2015·Journal of Neurosurgical Anesthesiology·Jing LiAlex Bekker
Mar 5, 2021·Alcohol·Fabio García-GarcíaCarolina Peña-Escudero
Aug 13, 2021·The American Journal of Drug and Alcohol Abuse·Aranza Wille-BilleRicardo Marcos Pautassi

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