Region-Specific Iron Measured by MRI as a Biomarker for Parkinson's Disease

Neuroscience Bulletin
Xiaojun GuanMinming Zhang

Abstract

The identification of sensitive and specific biomarkers for Parkinson's disease (PD) poses an important clinical challenge. A potential biomarker for early diagnosis and disease monitoring of PD is region-specific iron. Iron accumulation in the substantia nigra pars compacta is considered a main characteristic of PD. However, questions remain, such as the relationship between nigral iron and clinical indices of PD (motor impairment or disease duration). Further, previous studies have suggested the influence of iron on other nuclei. Iron quantification using magnetic resonance imaging (MRI) allows for studies of the relationship between regional iron and clinical symptoms in vivo. Thus, in this review we discuss the following topics: the technological development of MRI in measuring brain iron, nigral iron as a potential marker for PD in both clinical and prodromal stages, other influences of regional iron on PD, and clinical translation and future perspectives.

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Citations

Dec 29, 2017·Neuroscience Bulletin·Zhen-Yang LiuJian Wang
Oct 28, 2019·Neuroscience Bulletin·Tianbai Li, Weidong Le
Jun 14, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Huamin XuJunxia Xie
Feb 13, 2020·Current Opinion in Neurology·Germain Arribarat, Patrice Péran
Aug 23, 2017·Neuroscience Bulletin·Qiaoling ZengMinming Zhang
Aug 28, 2020·Frontiers in Neurology·Germain ArribaratPatrice Péran
Oct 4, 2018·Current Neurology and Neuroscience Reports·Jing YangDavid E Vaillancourt
Aug 11, 2021·Brain Structure & Function·Lu-Yan GuJiali Pu

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