Region-Specific Microstructure in the Neonatal Ventricles of a Porcine Model

Annals of Biomedical Engineering
F AhmadPeter Theobald

Abstract

The neonate transitions from placenta-derived oxygen, to supply from the pulmonary system, moments after birth. This requires a series of structural developments to divert more blood through the right heart and onto the lungs, with the tissue quickly remodelling to the changing ventricular workload. In some cases, however, the heart structure does not fully develop causing poor circulation and inefficient oxygenation, which is associated with an increase in mortality and morbidity. This study focuses on developing an enhanced knowledge of the 1-day old heart, quantifying the region-specific microstructural parameters of the tissue. This will enable more accurate mathematical and computational simulations of the young heart. Hearts were dissected from 12, 1-day-old deceased Yorkshire piglets (mass: 2.1-2.4 kg, length: 0.38-0.51 m), acquired from a breeding farm. Evans blue dye was used to label the heart equator and to demarcate the left and right ventricle free walls. Two hearts were used for three-dimensional diffusion-tensor magnetic resonance imaging, to quantify the fractional anisotropy (FA). The remaining hearts were used for two-photon excited fluorescence and second-harmonic generation microscopy, to quantify the cardio...Continue Reading

References

Jan 1, 1978·Biology of the Neonate·A H Cheema, S H Gilani
Feb 1, 1990·Pediatric Clinics of North America·J I Hoffman
May 1, 1974·Journal of Animal Science·S A Book, L K Bustad
Mar 1, 1970·Circulation Research·A M Rudolph, M A Heymann
Mar 1, 1994·Journal of Molecular and Cellular Cardiology·K T WeberJ P Cleutjens
Jun 1, 1996·Journal of Biomechanics·L A TaberW W Podszus
Oct 3, 1998·Journal of Anatomy·S J CrickR H Anderson
Dec 10, 1999·Biophysical Journal·P J CampagnolaL M Loew
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·W J KarlonJ H Omens
Sep 15, 2001·Mechanisms of Ageing and Development·M L BurgessH L Hedrick
Oct 25, 2006·The Journal of Thoracic and Cardiovascular Surgery·Ed PetrossianFrank L Hanley
Mar 9, 2007·World Journal of Surgery·Xinwen WangChangyi Chen
Apr 10, 1991·Applied Optics·Z Q Liu
Sep 2, 2010·IEEE Transactions on Medical Imaging·James G MalcolmYogesh Rathi
Nov 20, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Lei ZhangJunjie Chen
Dec 1, 2012·Stem Cells Translational Medicine·Hirotsugu KurobeToshiharu Shinoka
Feb 15, 2013·PloS One·Valentina CaorsiMike A Ferenczi
Jul 23, 2013·International Journal for Numerical Methods in Biomedical Engineering·Thomas S E ErikssonGerhard A Holzapfel
Aug 6, 2014·Proteomics. Clinical Applications·Anna BassolsJoan Tibau
Jul 5, 2015·Acta Biomaterialia·Gerhard SommerGerhard A Holzapfel
Nov 22, 2015·Journal of Cardiothoracic Surgery·Theodor TirilomisFriedrich A Schoendube
Aug 18, 2018·Journal of the Mechanical Behavior of Biomedical Materials·Faizan AhmadPeter S Theobald

❮ Previous
Next ❯

Methods Mentioned

BETA
light-scattering

Software Mentioned

ImageJ
Slicer
3D
SlicerDMRI
Image J
Fiji

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.